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10.1111/bjh.14307 http://scihub22266oqcxt.onion/10.1111/bjh.14307 C7161904!7161904!27539877     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Br+J+Haematol 2016 ; 175 (5): 956-66 Nephropedia Template TP {{tp|p=27539877|t=2016. Red cell alloimmunisation in patients with different types of infections |pdf=|usr=}}{{27539877}} gab.com Text Red cell alloimmunisation in patients with different types of infections JO: Br J Haematol http://www.kidney.de/pget.php?&tw=1&pmid=27539877 #FOAvip Red cell alloantigen exposure can cause alloantibody?associated morbidity. Murine models have suggested that inflammation modulates red cell alloimmunisation. This study quantifies alloimmunisation risks during infectious episodes in humans. We performed a multicentre case?control study within a source population of patients receiving their first and subsequent red cell transfusions during an 8?year follow?up period. Patients developing a first transfusion?induced red cell alloantibody (N = 505) were each compared with two similarly exposed, but non?alloimmunised controls (N = 1010) during a 5?week ?alloimmunisation risk period? using multivariate logistic regression analysis. Transfusions during ?severe? bacterial (tissue?invasive) infections were associated with increased risks of alloantibody development [adjusted relative risk (RR) 1·34, 95% confidence interval (95% CI) 0·97?1·85], especially when these infections were accompanied with long?standing fever (RR 3·06, 95% CI 1·57?5·96). Disseminated viral disorders demonstrated a trend towards increased risks (RR 2·41, 95% CI 0·89?6·53), in apparent contrast to a possible protection associated with Gram?negative bacteraemia (RR 0·58, 95% CI 0·13?1·14). ?Simple? bacterial infections, Gram?positive bacteraemia, fungal infections, maximum C?reactive protein values and leucocytosis were not associated with red cell alloimmunisation. These findings are consistent with murine models. Confirmatory research is needed before patients likely to develop alloantibodies may be identified based on their infectious conditions at time of transfusion. Twit Text FOAVip Red cell alloimmunisation in patients with different types of infections ????Br J Haematol http://www.kidney.de/pget.php?&tw=1&pmid=27539877 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27539877 #FOAvip English Wikipedia <ref>{{Cite pmid|27539877}}</ref> Red cell alloimmunisation in patients with different types of infections #MMPMID27539877 Evers D; van der Bom JG; Tijmensen J; Middelburg RA; de Haas M; Zalpuri S; de Vooght KMK; van de Kerkhof D; Visser O; Péquériaux NCV; Hudig F; Zwaginga JJ Br J Haematol 2016[Dec]; 175 (5): 956-66 PMID27539877show ga Red cell alloantigen exposure can cause alloantibody?associated morbidity. Murine models have suggested that inflammation modulates red cell alloimmunisation. This study quantifies alloimmunisation risks during infectious episodes in humans. We performed a multicentre case?control study within a source population of patients receiving their first and subsequent red cell transfusions during an 8?year follow?up period. Patients developing a first transfusion?induced red cell alloantibody (N = 505) were each compared with two similarly exposed, but non?alloimmunised controls (N = 1010) during a 5?week ?alloimmunisation risk period? using multivariate logistic regression analysis. Transfusions during ?severe? bacterial (tissue?invasive) infections were associated with increased risks of alloantibody development [adjusted relative risk (RR) 1·34, 95% confidence interval (95% CI) 0·97?1·85], especially when these infections were accompanied with long?standing fever (RR 3·06, 95% CI 1·57?5·96). Disseminated viral disorders demonstrated a trend towards increased risks (RR 2·41, 95% CI 0·89?6·53), in apparent contrast to a possible protection associated with Gram?negative bacteraemia (RR 0·58, 95% CI 0·13?1·14). ?Simple? bacterial infections, Gram?positive bacteraemia, fungal infections, maximum C?reactive protein values and leucocytosis were not associated with red cell alloimmunisation. These findings are consistent with murine models. Confirmatory research is needed before patients likely to develop alloantibodies may be identified based on their infectious conditions at time of transfusion. äRed cell alloimmunisation in patients with different types of infectio(epmc).pdf DeepDyve Pubget Overpricing