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2018 ; 7
(13
): e1701400
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Recent Advances in the Development of Antimicrobial Nanoparticles for Combating
Resistant Pathogens
#MMPMID29717819
Lakshminarayanan R
; Ye E
; Young DJ
; Li Z
; Loh XJ
Adv Healthc Mater
2018[Jul]; 7
(13
): e1701400
PMID29717819
show ga
The rapid growth of harmful pathogens and their multidrug-resistance poses a
severe challenge for health professionals and for the development of new
healthcare products. Various strategies are exploited for the development of
effective antimicrobial agents, and nanoparticles are a particularly promising
class of materials in this respect. This review summarizes recent advances in
antimicrobial metallic, polymeric, and lipid-based nanoparticles such as
liposomes, solid lipid nanoparticles, and nanostructured lipid carriers. The
latter materials in particular are engineered for antimicrobial agent delivery
and act by encapsulation, receptor-based binding, and disruption of microbial
adherence to cellular substrates. Potential strategies for the design of
multifunctional antimicrobial nanocarriers, combining material chemistry and
biological interface science, are also discussed.