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2018 ; 28
(34
): 1800960
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Host Cell Mimic Polymersomes for Rapid Detection of Highly Pathogenic Influenza
Virus via a Viral Fusion and Cell Entry Mechanism
#MMPMID32313543
Kim HO
; Na W
; Yeom M
; Choi J
; Kim J
; Lim JW
; Yun D
; Chun H
; Park G
; Park C
; Kim JK
; Jeong DG
; Le VP
; Lee K
; Lee JM
; Jeong HH
; Song D
; Haam S
Adv Funct Mater
2018[Aug]; 28
(34
): 1800960
PMID32313543
show ga
Highly pathogenic avian influenza virus (HPAIV) infections have occurred
continuously and crossed the species barrier to humans, leading to fatalities. A
polymerase chain reaction based molecular test is currently the most sensitive
diagnostic tool for HPAIV; however, the results must be analyzed in centralized
diagnosis systems by a trained individual. This requirement leads to delays in
quarantine and isolation. To control the spread of HPAIV, rapid and accurate
diagnostics suitable for field testing are needed, and the tests must facilitate
a differential diagnosis between HPAIV and low pathogenic avian influenza virus
(LPAIV), which undergo cleavage specifically by trypsin- or furin-like proteases,
respectively. In this study, a differential avian influenza virus rapid test kit
is developed and evaluated in vitro and using clinical specimens from HPAIV
H5N1-infected animals. It is demonstrated that this rapid test kit provides
highly sensitive and specific detection of HPAIV and LPAIV and is thus a useful
field diagnostic tool for H5N1 HPAIV outbreaks and for rapid quarantine control
of the disease.