Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1080/01902148.2020.1753266 http://scihub22266oqcxt.onion/10.1080/01902148.2020.1753266 C7157950!7157950 !32286085     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\32286085 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Exp+Lung+Res 2020 ; 46 (5 ): 157-161 Nephropedia Template TP {{tp|p=32286085 |t=2020. Dapsone as treatment adjunct in ARDS |pdf=|usr=}}{{32286085 }} gab.com Text Dapsone as treatment adjunct in ARDS JO: Exp Lung Res http://www.kidney.de/pget.php?&tw=1&pmid=32286085 #FOAvip Multiple pharmacological interventions tested over the last decades have failed to reduce ARDS mortality. This short note recounts past data indicating that (i) neutrophils home along an IL-8 gradient, (ii) in ARDS, massive neutrophil accumulation and degranulation in and along bronchoalveolar spaces contributes to damage and hypoxia, (iii) large increases in IL-8 are one of the chemotaxic signals drawing neutrophils to the ARDS lung, and (iv) old data from dermatology and glioblastoma research showed that the old drug against Hansen's disease, dapsone, inhibits neutrophils' chemotaxis to IL-8. Therefore dapsone might lower neutrophils' contributions to ARDS lung pathology. Dapsone can create methemoglobinemia that although rarely problematic it would be particularly undesirable in ARDS. The common antacid drug cimetidine lowers risk of dapsone related methemoglobinemia and should be given concomitantly. Twit Text FOAVip Dapsone as treatment adjunct in ARDS ????Exp Lung Res http://www.kidney.de/pget.php?&tw=1&pmid=32286085 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32286085 #FOAvip English Wikipedia <ref>{{Cite pmid|32286085 }}</ref> Dapsone as treatment adjunct in ARDS #MMPMID32286085 Kast RE Exp Lung Res 2020[May]; 46 (5 ): 157-161 PMID32286085 show ga Multiple pharmacological interventions tested over the last decades have failed to reduce ARDS mortality. This short note recounts past data indicating that (i) neutrophils home along an IL-8 gradient, (ii) in ARDS, massive neutrophil accumulation and degranulation in and along bronchoalveolar spaces contributes to damage and hypoxia, (iii) large increases in IL-8 are one of the chemotaxic signals drawing neutrophils to the ARDS lung, and (iv) old data from dermatology and glioblastoma research showed that the old drug against Hansen's disease, dapsone, inhibits neutrophils' chemotaxis to IL-8. Therefore dapsone might lower neutrophils' contributions to ARDS lung pathology. Dapsone can create methemoglobinemia that although rarely problematic it would be particularly undesirable in ARDS. The common antacid drug cimetidine lowers risk of dapsone related methemoglobinemia and should be given concomitantly. |Anti-Infective Agents/pharmacology/*therapeutic use [MESH] |Cimetidine/therapeutic use [MESH] |Dapsone/pharmacology/*therapeutic use [MESH] |Histamine H2 Antagonists/therapeutic use [MESH] |Humans [MESH] |Methemoglobinemia/chemically induced/prevention & control [MESH] |Neutrophils/*drug effects [MESH]Dapsone as treatment adjunct in ARDS (epmc).pdf DeepDyve Pubget Overpricing