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10.1186/s13567-020-00774-0 http://scihub22266oqcxt.onion/10.1186/s13567-020-00774-0 C7156904!7156904!32293543     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32293543&cmd=llinks): Failed to open stream: HTTP request failed! 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Newcastle disease virus RNA-induced IL-1? expression via the NLRP3/caspase-1 inflammasome |pdf=|usr=}}{{32293543}} gab.com Text Newcastle disease virus RNA-induced IL-1 expression via the NLRP3/caspase-1 inflammasome JO: Vet Res http://www.kidney.de/pget.php?&tw=1&pmid=32293543 #FOAvip Newcastle disease virus (NDV) infection causes severe inflammation and is a highly contagious disease in poultry. Virulent NDV strains (GM) induce large quantities of interleukin-1? (IL-1?), which is the central mediator of the inflammatory reaction. Excessive expression of IL-1? exacerbates inflammatory damage. Therefore, exploring the mechanisms underlying NDV-induced IL-1? expression can aid in further understanding the pathogenesis of Newcastle disease. Here, we showed that anti-IL-1? neutralizing antibody treatment decreased body temperature and mortality following infection with virulent NDV. We further explored the primary molecules involved in NDV-induced IL-1? expression from the perspective of both the host and virus. This study showed that overexpression of NLRP3 resulted in increased IL-1? expression, whereas inhibition of NLRP3 or caspase-1 caused a significant reduction in IL-1? expression, indicating that the NLRP3/caspase-1 axis is involved in NDV-induced IL-1? expression. Moreover, ultraviolet-inactivated GM (chicken/Guangdong/GM/2014) NDV failed to induce the expression of IL-1?. We then collected virus from GM-infected cell culture supernatant using ultracentrifugation, extracted the viral RNA, and stimulated the cells further with GM RNA. The results revealed that RNA alone was capable of inducing IL-1? expression. Moreover, NLRP3/caspase-1 was involved in GM RNA-induced IL-1? expression. Thus, our study elucidated the critical role of IL-1? in the pathogenesis of Newcastle disease while also demonstrating that inhibition of IL-1? via anti-IL-1? neutralizing antibodies decreased the damage associated with NDV infection; furthermore, GM RNA induced IL-1? expression via NLRP3/caspase-1. Twit Text FOAVip Newcastle disease virus RNA-induced IL-1 expression via the NLRP3/caspase-1 inflammasome ????Vet Res http://www.kidney.de/pget.php?&tw=1&pmid=32293543 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32293543 #FOAvip English Wikipedia <ref>{{Cite pmid|32293543}}</ref> Newcastle disease virus RNA-induced IL-1? expression via the NLRP3/caspase-1 inflammasome #MMPMID32293543 Gao P; Chen L; Fan L; Ren J; Du H; Sun M; Li Y; Xie P; Lin Q; Liao M; Xu C; Ning Z; Ding C; Xiang B; Ren T Vet Res 2020[]; 51 (ä): ä PMID32293543show ga Newcastle disease virus (NDV) infection causes severe inflammation and is a highly contagious disease in poultry. Virulent NDV strains (GM) induce large quantities of interleukin-1? (IL-1?), which is the central mediator of the inflammatory reaction. Excessive expression of IL-1? exacerbates inflammatory damage. Therefore, exploring the mechanisms underlying NDV-induced IL-1? expression can aid in further understanding the pathogenesis of Newcastle disease. Here, we showed that anti-IL-1? neutralizing antibody treatment decreased body temperature and mortality following infection with virulent NDV. We further explored the primary molecules involved in NDV-induced IL-1? expression from the perspective of both the host and virus. This study showed that overexpression of NLRP3 resulted in increased IL-1? expression, whereas inhibition of NLRP3 or caspase-1 caused a significant reduction in IL-1? expression, indicating that the NLRP3/caspase-1 axis is involved in NDV-induced IL-1? expression. Moreover, ultraviolet-inactivated GM (chicken/Guangdong/GM/2014) NDV failed to induce the expression of IL-1?. We then collected virus from GM-infected cell culture supernatant using ultracentrifugation, extracted the viral RNA, and stimulated the cells further with GM RNA. The results revealed that RNA alone was capable of inducing IL-1? expression. Moreover, NLRP3/caspase-1 was involved in GM RNA-induced IL-1? expression. Thus, our study elucidated the critical role of IL-1? in the pathogenesis of Newcastle disease while also demonstrating that inhibition of IL-1? via anti-IL-1? neutralizing antibodies decreased the damage associated with NDV infection; furthermore, GM RNA induced IL-1? expression via NLRP3/caspase-1. äNewcastle disease virus RNA-induced IL-1? expression via the NLRP3/cas(epmc).pdf DeepDyve Pubget Overpricing