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10.1016/j.jaci.2020.04.006

http://scihub22266oqcxt.onion/10.1016/j.jaci.2020.04.006
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suck abstract from ncbi


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pmid32294485
      J+Allergy+Clin+Immunol 2020 ; 146 (1 ): 110-118
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  • Risk factors for severity and mortality in adult COVID-19 inpatients in Wuhan #MMPMID32294485
  • Li X ; Xu S ; Yu M ; Wang K ; Tao Y ; Zhou Y ; Shi J ; Zhou M ; Wu B ; Yang Z ; Zhang C ; Yue J ; Zhang Z ; Renz H ; Liu X ; Xie J ; Xie M ; Zhao J
  • J Allergy Clin Immunol 2020[Jul]; 146 (1 ): 110-118 PMID32294485 show ga
  • BACKGROUND: In December 2019, the coronavirus disease 2019 (COVID-19) outbreak occurred in Wuhan. Data on the clinical characteristics and outcomes of patients with severe COVID-19 are limited. OBJECTIVE: We sought to evaluate the severity on admission, complications, treatment, and outcomes of patients with COVID-19. METHODS: Patients with COVID-19 admitted to Tongji Hospital from January 26, 2020, to February 5, 2020, were retrospectively enrolled and followed-up until March 3, 2020. Potential risk factors for severe COVID-19 were analyzed by a multivariable binary logistic model. Cox proportional hazard regression model was used for survival analysis in severe patients. RESULTS: We identified 269 (49.1%) of 548 patients as severe cases on admission. Older age, underlying hypertension, high cytokine levels (IL-2R, IL-6, IL-10, and TNF-?), and high lactate dehydrogenase level were significantly associated with severe COVID-19 on admission. The prevalence of asthma in patients with COVID-19 was 0.9%, markedly lower than that in the adult population of Wuhan. The estimated mortality was 1.1% in nonsevere patients and 32.5% in severe cases during the average 32 days of follow-up period. Survival analysis revealed that male sex, older age, leukocytosis, high lactate dehydrogenase level, cardiac injury, hyperglycemia, and high-dose corticosteroid use were associated with death in patients with severe COVID-19. CONCLUSIONS: Patients with older age, hypertension, and high lactate dehydrogenase level need careful observation and early intervention to prevent the potential development of severe COVID-19. Severe male patients with heart injury, hyperglycemia, and high-dose corticosteroid use may have a high risk of death.
  • |Adolescent [MESH]
  • |Adult [MESH]
  • |Aged [MESH]
  • |Aged, 80 and over [MESH]
  • |Betacoronavirus [MESH]
  • |COVID-19 [MESH]
  • |China/epidemiology [MESH]
  • |Cohort Studies [MESH]
  • |Comorbidity [MESH]
  • |Coronavirus Infections/*complications/*mortality [MESH]
  • |Female [MESH]
  • |Humans [MESH]
  • |Inpatients/statistics & numerical data [MESH]
  • |Male [MESH]
  • |Middle Aged [MESH]
  • |Pandemics [MESH]
  • |Pneumonia, Viral/*complications/*mortality [MESH]
  • |Risk Factors [MESH]
  • |SARS-CoV-2 [MESH]
  • |Treatment Outcome [MESH]


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