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COVID-19 for the Cardiologist: Basic Virology, Epidemiology, Cardiac
Manifestations, and Potential Therapeutic Strategies
#MMPMID32292848
Atri D
; Siddiqi HK
; Lang JP
; Nauffal V
; Morrow DA
; Bohula EA
JACC Basic Transl Sci
2020[May]; 5
(5
): 518-536
PMID32292848
show ga
Coronavirus disease-2019 (COVID-19), a contagious disease caused by severe acute
respiratory syndrome-coronavirus-2 (SARS-CoV-2), has reached pandemic status. As
it spreads across the world, it has overwhelmed health care systems, strangled
the global economy, and led to a devastating loss of life. Widespread efforts
from regulators, clinicians, and scientists are driving a rapid expansion of
knowledge of the SARS-CoV-2 virus and COVID-19. The authors review the most
current data, with a focus on the basic understanding of the mechanism(s) of
disease and translation to the clinical syndrome and potential therapeutics. The
authors discuss the basic virology, epidemiology, clinical manifestation,
multiorgan consequences, and outcomes. With a focus on cardiovascular
complications, they propose several mechanisms of injury. The virology and
potential mechanism of injury form the basis for a discussion of potential
disease-modifying therapies.
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