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10.1111/1469-0691.12403 http://scihub22266oqcxt.onion/10.1111/1469-0691.12403 C7129123!7129123!24283933     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 276.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 276.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 276.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 276.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Clin+Microbiol+Infect 2014 ; 20 (5): O325-32 Nephropedia Template TP {{tp|p=24283933|t=2014. The allele 4 of neck region liver?lymph node?specific ICAM?3?grabbing integrin variant is associated with spontaneous clearance of hepatitis C virus and decrease of viral loads |pdf=|usr=}}{{24283933}} gab.com Text The allele 4 of neck region liver lymph node specific ICAM 3 grabbing integrin variant is associated with spontaneous clearance of hepatitis C virus and decrease of viral loads JO: Clin Microbiol Infect http://www.kidney.de/pget.php?&tw=1&pmid=24283933 #FOAvip L?SIGN is a C?type lectin expressed on liver sinusoidal endothelial cells involved in the capture of hepatitis C virus and trans?infection of adjacent hepatocyte cells. The neck region of L?SIGN is highly polymorphic, with three to nine tandem repeats of 23 residues. This polymorphism is associated with a number of infectious diseases, but has not been explored in HCV. We therefore investigated the impact of L?SIGN neck region length variation on the outcome of HCV infection. We studied 322 subjects, 150 patients with persistent HCV infection, 63 individuals with spontaneous clearance and 109 healthy controls. In healthy subjects, we found a total of nine genotypes, with the 7/7 genotype being the most frequent (33%) followed by the 7/6 (22.9%) and the 7/5 (18.3%). The frequencies of the alleles were as follows: 7?LSIGN (56.4%), 6?LSIGN (20.2%), 5?L?SIGN (18.3%) and 4?L?SIGN (5%). The frequency of the 7/4 genotype was higher in spontaneous resolvers (14.3%) as compared with the persistent group (4%) (OR = 0.25, 95% CI = 0.07?0.82, p 0.022). In addition, we found that 4?L?SIGN was associated with spontaneous resolution of HCV infection (OR = 0.30, 95%CI, 0.12?0.74, p 0.005). Interestingly, patients with 4?L?SIGN had lower viral loads when compared with carriers of the 5 (p 0.001), 6 (p 0.021) and 7?alleles (p 0.048). The results indicate that neck region polymorphism of L?SIGN can influence the outcome of HCV infection and the four?tandem repeat is associated with clearance of HCV infection. Twit Text FOAVip The allele 4 of neck region liver lymph node specific ICAM 3 grabbing integrin variant is associated with spontaneous clearance of hepatitis C virus and decrease of viral loads ????Clin Microbiol Infect http://www.kidney.de/pget.php?&tw=1&pmid=24283933 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24283933 #FOAvip English Wikipedia <ref>{{Cite pmid|24283933}}</ref> The allele 4 of neck region liver?lymph node?specific ICAM?3?grabbing integrin variant is associated with spontaneous clearance of hepatitis C virus and decrease of viral loads #MMPMID24283933 Ezzikouri S; Rebbani K; Fakhir F; Alaoui R; Nadir S; Diepolder H; Thursz M; Khakoo SI; Benjelloun S Clin Microbiol Infect 2014[May]; 20 (5): O325-32 PMID24283933show ga L?SIGN is a C?type lectin expressed on liver sinusoidal endothelial cells involved in the capture of hepatitis C virus and trans?infection of adjacent hepatocyte cells. The neck region of L?SIGN is highly polymorphic, with three to nine tandem repeats of 23 residues. This polymorphism is associated with a number of infectious diseases, but has not been explored in HCV. We therefore investigated the impact of L?SIGN neck region length variation on the outcome of HCV infection. We studied 322 subjects, 150 patients with persistent HCV infection, 63 individuals with spontaneous clearance and 109 healthy controls. In healthy subjects, we found a total of nine genotypes, with the 7/7 genotype being the most frequent (33%) followed by the 7/6 (22.9%) and the 7/5 (18.3%). The frequencies of the alleles were as follows: 7?LSIGN (56.4%), 6?LSIGN (20.2%), 5?L?SIGN (18.3%) and 4?L?SIGN (5%). The frequency of the 7/4 genotype was higher in spontaneous resolvers (14.3%) as compared with the persistent group (4%) (OR = 0.25, 95% CI = 0.07?0.82, p 0.022). In addition, we found that 4?L?SIGN was associated with spontaneous resolution of HCV infection (OR = 0.30, 95%CI, 0.12?0.74, p 0.005). Interestingly, patients with 4?L?SIGN had lower viral loads when compared with carriers of the 5 (p 0.001), 6 (p 0.021) and 7?alleles (p 0.048). The results indicate that neck region polymorphism of L?SIGN can influence the outcome of HCV infection and the four?tandem repeat is associated with clearance of HCV infection. äThe allele 4 of neck region liver?lymph node?specific ICAM?3?grabbing (epmc).pdf DeepDyve Pubget Overpricing