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Solid supported lipid bilayers: From biophysical studies to sensor design
#MMPMID32287559
Castellana ET
; Cremer PS
Surf Sci Rep
2006[Nov]; 61
(10
): 429-444
PMID32287559
show ga
The lipid bilayer is one of the most eloquent and important self-assembled
structures in nature. It not only provides a protective container for cells and
sub-cellular compartments, but also hosts much of the machinery for cellular
communication and transport across the cell membrane. Solid supported lipid
bilayers provide an excellent model system for studying the surface chemistry of
the cell. Moreover, they are accessible to a wide variety of surface-specific
analytical techniques. This makes it possible to investigate processes such as
cell signaling, ligand-receptor interactions, enzymatic reactions occurring at
the cell surface, as well as pathogen attack. In this review, the following
membrane systems are discussed: black lipid membranes, solid supported lipid
bilayers, hybrid lipid bilayers, and polymer cushioned lipid bilayers. Examples
of how supported lipid membrane technology is interfaced with array based systems
by photolithographic patterning, spatial addressing, microcontact printing, and
microfluidic patterning are explored. Also, the use of supported lipid bilayers
in microfluidic devices for the development of lab-on-a-chip based platforms is
examined. Finally, the utility of lipid bilayers in nanotechnology and future
directions in this area are discussed.
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