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10.1016/j.virol.2006.03.036 http://scihub22266oqcxt.onion/10.1016/j.virol.2006.03.036 C7111820!7111820 !16690096     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=16690096 &cmd=llinks): Failed to open stream: HTTP request failed! 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Long-lived memory T lymphocyte responses against SARS coronavirus nucleocapsid protein in SARS-recovered patients |pdf=|usr=}}{{16690096 }} gab.com Text Long-lived memory T lymphocyte responses against SARS coronavirus nucleocapsid protein in SARS-recovered patients JO: Virology http://www.kidney.de/pget.php?&tw=1&pmid=16690096 #FOAvip The nucleocapsid (N) protein is a structural component of severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV) and can induce antibody responses in SARS patients during infection. However, it is not known whether SARS-CoV N protein can induce a long persistence of memory T-cell response in human. In this study, we found that peripheral blood mononuclear cells (PBMCs) from fully recovered SARS individuals rapidly produced IFN-gamma and IL-2 following stimulation with a pool of overlapping peptides that cover the entire N protein sequence. The N-specific IFN-gamma(+)CD4(+) T cells were mainly composed of CD45RA(-)CCR7(+)CD62L(-) cells, whereas IFN-gamma(+)CD8(+) memory T cells were mostly contained within CD45RA(+)CCR7(-)CD62L(-) cell population. Epitope mapping study indicated that a cluster of overlapping peptides located in the C-terminal region (amino acids [aa] 331 to 362) of N protein contained at least two different T-cell epitopes. The results indicated that human memory T-cell responses specific for SARS-CoV N protein could persist for 2 years in the absence of antigen, which would be a valuable for the design of effective vaccines against SARS-CoV and for basic studies of human T-cell memory. Twit Text FOAVip Long-lived memory T lymphocyte responses against SARS coronavirus nucleocapsid protein in SARS-recovered patients ????Virology http://www.kidney.de/pget.php?&tw=1&pmid=16690096 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=16690096 #FOAvip English Wikipedia <ref>{{Cite pmid|16690096 }}</ref> Long-lived memory T lymphocyte responses against SARS coronavirus nucleocapsid protein in SARS-recovered patients #MMPMID16690096 Peng H ; Yang LT ; Wang LY ; Li J ; Huang J ; Lu ZQ ; Koup RA ; Bailer RT ; Wu CY Virology 2006[Aug]; 351 (2 ): 466-75 PMID16690096 show ga The nucleocapsid (N) protein is a structural component of severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV) and can induce antibody responses in SARS patients during infection. However, it is not known whether SARS-CoV N protein can induce a long persistence of memory T-cell response in human. In this study, we found that peripheral blood mononuclear cells (PBMCs) from fully recovered SARS individuals rapidly produced IFN-gamma and IL-2 following stimulation with a pool of overlapping peptides that cover the entire N protein sequence. The N-specific IFN-gamma(+)CD4(+) T cells were mainly composed of CD45RA(-)CCR7(+)CD62L(-) cells, whereas IFN-gamma(+)CD8(+) memory T cells were mostly contained within CD45RA(+)CCR7(-)CD62L(-) cell population. Epitope mapping study indicated that a cluster of overlapping peptides located in the C-terminal region (amino acids [aa] 331 to 362) of N protein contained at least two different T-cell epitopes. The results indicated that human memory T-cell responses specific for SARS-CoV N protein could persist for 2 years in the absence of antigen, which would be a valuable for the design of effective vaccines against SARS-CoV and for basic studies of human T-cell memory. |CD4-Positive T-Lymphocytes/*immunology [MESH] |CD8-Positive T-Lymphocytes/*immunology [MESH] |Coronavirus Nucleocapsid Proteins [MESH] |Female [MESH] |Humans [MESH] |Immunologic Memory/*immunology [MESH] |Interferon-gamma/metabolism [MESH] |Male [MESH] |Nucleocapsid Proteins/*immunology [MESH] |Severe Acute Respiratory Syndrome/*immunology/virology [MESH]Long-lived memory T lymphocyte responses against SARS coronavirus nucl(epmc).pdf DeepDyve Pubget Overpricing