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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Virology
2005 ; 340
(2
): 174-82
Nephropedia Template TP
gab.com Text
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English Wikipedia
Long-term protection from SARS coronavirus infection conferred by a single
immunization with an attenuated VSV-based vaccine
#MMPMID16043204
Kapadia SU
; Rose JK
; Lamirande E
; Vogel L
; Subbarao K
; Roberts A
Virology
2005[Sep]; 340
(2
): 174-82
PMID16043204
show ga
Although the recent SARS coronavirus (SARS-CoV) that appeared in 2002 has now
been contained, the possibility of re-emergence of SARS-CoV remains. Due to the
threat of re-emergence, the overall fatality rate of approximately 10%, and the
rapid dispersion of the virus via international travel, viable vaccine candidates
providing protection from SARS are clearly needed. We developed an attenuated VSV
recombinant (VSV-S) expressing the SARS coronavirus (SARS-CoV) spike (S) protein.
In cells infected with this recombinant, S protein was synthesized, glycosylated
at approximately 17 Asn residues, and transported via the Golgi to the cell
surface. Mice vaccinated with VSV-S developed SARS-neutralizing antibody and were
able to control a challenge with SARS-CoV performed at 1 month or 4 months after
a single vaccination. We also demonstrated, by passive antibody transfer, that
the antibody response induced by the vaccine was sufficient for controlling
SARS-CoV infection. A VSV-vectored SARS vaccine could have significant advantages
over other SARS vaccine candidates described to date.