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10.1093/nsr/nwaa037 http://scihub22266oqcxt.onion/10.1093/nsr/nwaa037 C7107806!7107806!34676126     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Natl+Sci+Rev 2020 ; 7 (6): 1003-11 Nephropedia Template TP {{tp|p=34676126|t=2020. Elevated plasma levels of selective cytokines in COVID-19 patients reflect viral load and lung injury |pdf=|usr=}}{{34676126}} gab.com Text Elevated plasma levels of selective cytokines in COVID-19 patients reflect viral load and lung injury JO: Natl Sci Rev http://www.kidney.de/pget.php?&tw=1&pmid=34676126 #FOAvip A recent outbreak of pneumonia in Wuhan, China was found to be caused by a 2019 novel coronavirus (2019-nCoV or SARS-CoV-2 or HCoV-19). We previously reported the clinical features of 12 patients with 2019-nCoV infections in Shenzhen, China. To further understand the pathogenesis of COVID-19 and find better ways to monitor and treat the disease caused by 2019-nCoV, we measured the levels of 48 cytokines in the blood plasma of those 12 COVID-19 patients. Thirty-eight out of the 48 measured cytokines in the plasma of 2019-nCoV-infected patients were significantly elevated compared to healthy individuals. Seventeen cytokines were linked to 2019-nCoV loads. Fifteen cytokines, namely M-CSF, IL-10, IFN-?2, IL-17, IL-4, IP-10, IL-7, IL-1ra, G-CSF, IL-12, IFN-?, IL-1?, IL-2, HGF and PDGF-BB, were strongly associated with the lung-injury Murray score and could be used to predict the disease severity of 2019-nCoV infections by calculating the area under the curve of the receiver-operating characteristics. Our results suggest that 2019-nCoV infections trigger extensive changes in a wide array of cytokines, some of which could be potential biomarkers of disease severity of 2019-nCoV infections. These findings will likely improve our understanding of the immunopathologic mechanisms of this emerging disease. Our results also suggest that modulators of cytokine responses may play a therapeutic role in combating the disease once the functions of these elevated cytokines have been characterized. Twit Text FOAVip Elevated plasma levels of selective cytokines in COVID-19 patients reflect viral load and lung injury ????Natl Sci Rev http://www.kidney.de/pget.php?&tw=1&pmid=34676126 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34676126 #FOAvip English Wikipedia <ref>{{Cite pmid|34676126}}</ref> Elevated plasma levels of selective cytokines in COVID-19 patients reflect viral load and lung injury #MMPMID34676126 Liu Y; Zhang C; Huang F; Yang Y; Wang F; Yuan J; Zhang Z; Qin Y; Li X; Zhao D; Li S; Tan S; Wang Z; Li J; Shen C; Li J; Peng L; Wu W; Cao M; Xing L; Xu Z; Chen L; Zhou C; Liu WJ; Liu L; Jiang C Natl Sci Rev 2020[Jun]; 7 (6): 1003-11 PMID34676126show ga A recent outbreak of pneumonia in Wuhan, China was found to be caused by a 2019 novel coronavirus (2019-nCoV or SARS-CoV-2 or HCoV-19). We previously reported the clinical features of 12 patients with 2019-nCoV infections in Shenzhen, China. To further understand the pathogenesis of COVID-19 and find better ways to monitor and treat the disease caused by 2019-nCoV, we measured the levels of 48 cytokines in the blood plasma of those 12 COVID-19 patients. Thirty-eight out of the 48 measured cytokines in the plasma of 2019-nCoV-infected patients were significantly elevated compared to healthy individuals. Seventeen cytokines were linked to 2019-nCoV loads. Fifteen cytokines, namely M-CSF, IL-10, IFN-?2, IL-17, IL-4, IP-10, IL-7, IL-1ra, G-CSF, IL-12, IFN-?, IL-1?, IL-2, HGF and PDGF-BB, were strongly associated with the lung-injury Murray score and could be used to predict the disease severity of 2019-nCoV infections by calculating the area under the curve of the receiver-operating characteristics. Our results suggest that 2019-nCoV infections trigger extensive changes in a wide array of cytokines, some of which could be potential biomarkers of disease severity of 2019-nCoV infections. These findings will likely improve our understanding of the immunopathologic mechanisms of this emerging disease. Our results also suggest that modulators of cytokine responses may play a therapeutic role in combating the disease once the functions of these elevated cytokines have been characterized. äElevated plasma levels of selective cytokines in COVID-19 patients ref(epmc).pdf DeepDyve Pubget Overpricing