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10.3748/wjg.v26.i11.1142 http://scihub22266oqcxt.onion/10.3748/wjg.v26.i11.1142 C7093313!7093313 !32231419     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32231419 &cmd=llinks): Failed to open stream: HTTP request failed! 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Effect of prolonged omeprazole administration on segmental intestinal Mg(2+) absorption in male Sprague-Dawley rats |pdf=|usr=}}{{32231419 }} gab.com Text Effect of prolonged omeprazole administration on segmental intestinal Mg(2+) absorption in male Sprague-Dawley rats JO: World J Gastroenterol http://www.kidney.de/pget.php?&tw=1&pmid=32231419 #FOAvip BACKGROUND: The exact mechanism of proton pump inhibitors (PPIs)-induced hypomagnesemia (PPIH) is largely unknown. Previous studies proposed that PPIH is a consequence of intestinal Mg(2+) malabsorption. However, the mechanism of PPIs-suppressed intestinal Mg(2+) absorption is under debate. AIM: To investigate the effect of 12-wk and 24-wk omeprazole injection on the total, transcellular, and paracellular Mg(2+) absorption in the duodenum, jejunum, ileum, and colon of male Sprague-Dawley rats. METHODS: The rats received 20 mg/kg?d subcutaneous omeprazole injection for 12 or 24 wk. Plasma and urinary Mg(2+), Ca(2+), and PO(4) (3-) levels were measured. The plasma concentrations of 1?,25-dihydroxyvitamin D(3) (1?,25(OH)(2)D(3)), parathyroid hormone (PTH), fibroblast growth factor 23 (FGF-23), epidermal growth factor (EGF), and insulin were also observed. The duodenum, jejunum, ileum, and colon of each rat were mounted onto individual modified Using chamber setups to study the rates of total, transcellular, and paracellular Mg(2+) absorption simultaneously. The expression of transient receptor potential melastatin 6 (TRPM6) and cyclin M4 (CNNM4) in the entire intestinal tract was also measured. RESULTS: Single-dose omeprazole injection significantly increased the intraluminal pH of the stomach, duodenum, and jejunum. Omeprazole injection for 12 and 24 wk induced hypomagnesemia with reduced urinary Mg(2+) excretion. The plasma Ca(2+) was normal but the urinary Ca(2+) excretion was reduced in rats with PPIH. The plasma and urinary PO(4) (3-) levels increased in PPIH rats. The levels of 1?,25(OH)(2)D(3) and FGF-23 increased, whereas that of plasma EGF decreased in the omeprazole-treated rats. The rates of the total, transcellular, and paracellular Mg(2+) absorption was significantly lower in the duodenum, jejunum, ileum, and colon of the rats with PPIH than in those of the control rats. The percent suppression of Mg(2+) absorption in the duodenum, jejunum, ileum, and colon of the rats with PPIH compared with the control rats was 81.86%, 70.59%, 69.45%, and 39.25%, respectively. Compared with the control rats, the rats with PPIH had significantly higher TRPM6 and CNNM4 expression levels throughout the intestinal tract. CONCLUSION: Intestinal Mg(2+) malabsorption was observed throughout the intestinal tract of rats with PPIH. PPIs mainly suppressed small intestinal Mg(2+) absorption. Omeprazole exerted no effect on the intraluminal acidic pH in the colon. Thus, the lowest percent suppression of total Mg(2+) absorption was found in the colon. The expression levels of TRPM6 and CNNM4 increased, indicating the presence of a compensatory response to Mg(2+) malabsorption in rats with PPIH. Therefore, the small intestine is an appropriate segment that should be modulated to counteract PPIH. Twit Text FOAVip Effect of prolonged omeprazole administration on segmental intestinal Mg(2+) absorption in male Sprague-Dawley rats ????World J Gastroenterol http://www.kidney.de/pget.php?&tw=1&pmid=32231419 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32231419 #FOAvip English Wikipedia <ref>{{Cite pmid|32231419 }}</ref> Effect of prolonged omeprazole administration on segmental intestinal Mg(2+) absorption in male Sprague-Dawley rats #MMPMID32231419 Suksridechacin N ; Kulwong P ; Chamniansawat S ; Thongon N World J Gastroenterol 2020[Mar]; 26 (11 ): 1142-1155 PMID32231419 show ga BACKGROUND: The exact mechanism of proton pump inhibitors (PPIs)-induced hypomagnesemia (PPIH) is largely unknown. Previous studies proposed that PPIH is a consequence of intestinal Mg(2+) malabsorption. However, the mechanism of PPIs-suppressed intestinal Mg(2+) absorption is under debate. AIM: To investigate the effect of 12-wk and 24-wk omeprazole injection on the total, transcellular, and paracellular Mg(2+) absorption in the duodenum, jejunum, ileum, and colon of male Sprague-Dawley rats. METHODS: The rats received 20 mg/kg?d subcutaneous omeprazole injection for 12 or 24 wk. Plasma and urinary Mg(2+), Ca(2+), and PO(4) (3-) levels were measured. The plasma concentrations of 1?,25-dihydroxyvitamin D(3) (1?,25(OH)(2)D(3)), parathyroid hormone (PTH), fibroblast growth factor 23 (FGF-23), epidermal growth factor (EGF), and insulin were also observed. The duodenum, jejunum, ileum, and colon of each rat were mounted onto individual modified Using chamber setups to study the rates of total, transcellular, and paracellular Mg(2+) absorption simultaneously. The expression of transient receptor potential melastatin 6 (TRPM6) and cyclin M4 (CNNM4) in the entire intestinal tract was also measured. RESULTS: Single-dose omeprazole injection significantly increased the intraluminal pH of the stomach, duodenum, and jejunum. Omeprazole injection for 12 and 24 wk induced hypomagnesemia with reduced urinary Mg(2+) excretion. The plasma Ca(2+) was normal but the urinary Ca(2+) excretion was reduced in rats with PPIH. The plasma and urinary PO(4) (3-) levels increased in PPIH rats. The levels of 1?,25(OH)(2)D(3) and FGF-23 increased, whereas that of plasma EGF decreased in the omeprazole-treated rats. The rates of the total, transcellular, and paracellular Mg(2+) absorption was significantly lower in the duodenum, jejunum, ileum, and colon of the rats with PPIH than in those of the control rats. The percent suppression of Mg(2+) absorption in the duodenum, jejunum, ileum, and colon of the rats with PPIH compared with the control rats was 81.86%, 70.59%, 69.45%, and 39.25%, respectively. Compared with the control rats, the rats with PPIH had significantly higher TRPM6 and CNNM4 expression levels throughout the intestinal tract. CONCLUSION: Intestinal Mg(2+) malabsorption was observed throughout the intestinal tract of rats with PPIH. PPIs mainly suppressed small intestinal Mg(2+) absorption. Omeprazole exerted no effect on the intraluminal acidic pH in the colon. Thus, the lowest percent suppression of total Mg(2+) absorption was found in the colon. The expression levels of TRPM6 and CNNM4 increased, indicating the presence of a compensatory response to Mg(2+) malabsorption in rats with PPIH. Therefore, the small intestine is an appropriate segment that should be modulated to counteract PPIH. |Animals [MESH] |Cation Transport Proteins/analysis/metabolism [MESH] |Colon/drug effects/metabolism [MESH] |Disease Models, Animal [MESH] |Drug Administration Schedule [MESH] |Duodenum/drug effects/metabolism [MESH] |Fibroblast Growth Factor-23 [MESH] |Humans [MESH] |Ileum/drug effects/metabolism [MESH] |Injections, Subcutaneous [MESH] |Intestinal Absorption/*drug effects [MESH] |Intestinal Mucosa/drug effects/metabolism [MESH] |Jejunum/drug effects/metabolism [MESH] |Magnesium/*blood/metabolism [MESH] |Malabsorption Syndromes/blood/*chemically induced/diagnosis [MESH] |Male [MESH] |Omeprazole/*administration & dosage/adverse effects [MESH] |Proton Pump Inhibitors/*administration & dosage/adverse effects [MESH] |Rats [MESH] |Rats, Sprague-Dawley [MESH]Effect of prolonged omeprazole administration on segmental intestinal (epmc).pdf DeepDyve Pubget Overpricing