Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1038/s41390-019-0557-7 http://scihub22266oqcxt.onion/10.1038/s41390-019-0557-7 C7035964!7035964!31493768     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Pediatr+Res 2020 ; 87 (3): 463-71 Nephropedia Template TP {{tp|p=31493768|t=2020. Magnesium Sulfate Inhibits Inflammation Through P2X7 Receptors In Human Umbilical Vein Endothelial Cells |pdf=|usr=}}{{31493768}} gab.com Text Magnesium Sulfate Inhibits Inflammation Through P2X7 Receptors In Human Umbilical Vein Endothelial Cells JO: Pediatr Res http://www.kidney.de/pget.php?&tw=1&pmid=31493768 #FOAvip Introduction:: Magnesium sulfate (MgSO4) is utilized for fetal neuroprotection in preterm birth but its mechanism of action is still poorly understood. P2X7 receptor (P2X7R) is required for secretion of IL-1?, and can be blocked by divalent cations such as magnesium (Mg) and its own antagonist, Brilliant Blue G (BBG). We sought to determine, whether during inflammation MgSO4 can block endothelial IL-1? secretion, using an in-vitro model. Methods:: Human umbilical vein endothelial cell (HUVEC) cultures were treated with varying doses of LPS, 2?(3)-O-(4-Benzoylbenzoyl) adenosine-5?-triphosphate (BzATP), BBG and MgSO4 for 3- or 24-hours. We determined cell cytotoxicity, apoptosis, IL-1? mRNA expression, IL-1? production and secretion and P2X7R expression on HUVECs. Results:: We demonstrated that MgSO4 is efficacious in blocking IL-1?-mediated-inflammation in HUVECs, at both the initiation and propagation phases of inflammation. MgSO4 exerts these anti-inflammatory effects via downregulation of P2X7Rs on HUVECs. Conclusion:: LPS-exposure increases IL-1? production and secretion in HUVECs, which is further intensified by P2X7R agonist, BzATP while MgSO4 inhibits IL-1? in both presence and absence of BzATP. This effect is similar to the results of P2X7R antagonist, BBG, suggesting that the anti-inflammatory effects of MgSO4is through P2X7R. Twit Text FOAVip Magnesium Sulfate Inhibits Inflammation Through P2X7 Receptors In Human Umbilical Vein Endothelial Cells ????Pediatr Res http://www.kidney.de/pget.php?&tw=1&pmid=31493768 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=31493768 #FOAvip English Wikipedia <ref>{{Cite pmid|31493768}}</ref> Magnesium Sulfate Inhibits Inflammation Through P2X7 Receptors In Human Umbilical Vein Endothelial Cells #MMPMID31493768 Ozen M; Xie H; Shin N; Yousif GA; Clemens J; McLane MW; Lei J; Burd I Pediatr Res 2020[Feb]; 87 (3): 463-71 PMID31493768show ga Introduction:: Magnesium sulfate (MgSO4) is utilized for fetal neuroprotection in preterm birth but its mechanism of action is still poorly understood. P2X7 receptor (P2X7R) is required for secretion of IL-1?, and can be blocked by divalent cations such as magnesium (Mg) and its own antagonist, Brilliant Blue G (BBG). We sought to determine, whether during inflammation MgSO4 can block endothelial IL-1? secretion, using an in-vitro model. Methods:: Human umbilical vein endothelial cell (HUVEC) cultures were treated with varying doses of LPS, 2?(3)-O-(4-Benzoylbenzoyl) adenosine-5?-triphosphate (BzATP), BBG and MgSO4 for 3- or 24-hours. We determined cell cytotoxicity, apoptosis, IL-1? mRNA expression, IL-1? production and secretion and P2X7R expression on HUVECs. Results:: We demonstrated that MgSO4 is efficacious in blocking IL-1?-mediated-inflammation in HUVECs, at both the initiation and propagation phases of inflammation. MgSO4 exerts these anti-inflammatory effects via downregulation of P2X7Rs on HUVECs. Conclusion:: LPS-exposure increases IL-1? production and secretion in HUVECs, which is further intensified by P2X7R agonist, BzATP while MgSO4 inhibits IL-1? in both presence and absence of BzATP. This effect is similar to the results of P2X7R antagonist, BBG, suggesting that the anti-inflammatory effects of MgSO4is through P2X7R. äMagnesium Sulfate Inhibits Inflammation Through P2X7 Receptors In Huma(epmc).pdf DeepDyve Pubget Overpricing