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2020 ; 9
(2
): e973
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
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English Wikipedia
Comparative genomics of hepatitis A virus, hepatitis C virus, and hepatitis E
virus provides insights into the evolutionary history of Hepatovirus species
#MMPMID31742930
Wassenaar TM
; Jun SR
; Robeson M
; Ussery DW
Microbiologyopen
2020[Feb]; 9
(2
): e973
PMID31742930
show ga
The intraspecies genomic diversity of the single-strand RNA (+) virus species
hepatitis A virus (Hepatovirus), hepatitis C virus (Hepacivirus), and hepatitis E
virus (Orthohepevirus) was compared. These viral species all can cause liver
inflammation (hepatitis), but share no gene similarity. The codon usage of human
hepatitis A virus (HAV) is suboptimal for replication in its host, a
characteristic it shares with taxonomically related rodent, simian, and bat
hepatitis A virus species. We found this codon usage to be strikingly similar to
that of Triatoma virus that infects blood-sucking kissing bugs. The codon usage
of that virus is well adapted to its insect host. The codon usage of HAV is also
similar to other invertebrate viruses of various taxonomic families. An
evolutionary ancestor of HAV and related virus species is hypothesized to be an
insect virus that underwent a host jump to infect mammals. The similarity between
HAV and invertebrate viruses goes beyond codon usage, as they also share amino
acid composition characteristics, while not sharing direct sequence homology. In
contrast, hepatitis C virus and hepatitis E virus are highly similar in codon
usage preference, nucleotide composition, and amino acid composition, and share
these characteristics with Human pegivirus A, West Nile virus, and Zika virus. We
present evidence that these observations are only partly explained by differences
in nucleotide composition of the complete viral codon regions. We consider the
combination of nucleotide composition, amino acid composition, and codon usage
preference suitable to provide information on possible evolutionary similarities
between distant virus species that cannot be investigated by phylogeny.
|*Evolution, Molecular
[MESH]
|*Genome, Viral
[MESH]
|*Genomics/methods
[MESH]
|Codon
[MESH]
|Hepacivirus/classification/*genetics
[MESH]
|Hepatitis A virus/classification/*genetics
[MESH]
|Hepatitis E virus/classification/*genetics
[MESH]