Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.15252/embj.2019103205 http://scihub22266oqcxt.onion/10.15252/embj.2019103205 C6996567!6996567!31894879     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       EMBO+J 2020 ; 39 (3): ä Nephropedia Template TP {{tp|p=31894879|t=2020. Fetal monocytes possess increased metabolic capacity and replace primitive macrophages in tissue macrophage development |pdf=|usr=}}{{31894879}} gab.com Text Fetal monocytes possess increased metabolic capacity and replace primitive macrophages in tissue macrophage development JO: EMBO J http://www.kidney.de/pget.php?&tw=1&pmid=31894879 #FOAvip Tissue?resident macrophages (M?TR) originate from at least two distinct waves of erythro?myeloid progenitors (EMP) arising in the yolk sac (YS) at E7.5 and E8.5 with the latter going through a liver monocyte intermediate. The relative potential of these precursors in determining development and functional capacity of M?TR remains unclear. Here, we studied development of alveolar macrophages (AM) after single and competitive transplantation of different precursors from YS, fetal liver, and fetal lung into neonatal Csf2ra?/? mice, which lack endogenous AM. Fetal monocytes, promoted by Myb, outcompeted primitive M? (pM?) in empty AM niches and preferentially developed to mature AM, which is associated with enhanced mitochondrial respiratory and glycolytic capacity and repression of the transcription factors c?Maf and MafB. Interestingly, AM derived from pM? failed to efficiently clear alveolar proteinosis and protect from fatal lung failure following influenza virus infection. Thus, our data demonstrate superior developmental and functional capacity of fetal monocytes over pM? in AM development and underlying mechanisms explaining replacement of pM? in fetal tissues. Twit Text FOAVip Fetal monocytes possess increased metabolic capacity and replace primitive macrophages in tissue macrophage development ????EMBO J http://www.kidney.de/pget.php?&tw=1&pmid=31894879 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=31894879 #FOAvip English Wikipedia <ref>{{Cite pmid|31894879}}</ref> Fetal monocytes possess increased metabolic capacity and replace primitive macrophages in tissue macrophage development #MMPMID31894879 Li F; Okreglicka KM; Pohlmeier LM; Schneider C; Kopf M EMBO J 2020[Feb]; 39 (3): ä PMID31894879show ga Tissue?resident macrophages (M?TR) originate from at least two distinct waves of erythro?myeloid progenitors (EMP) arising in the yolk sac (YS) at E7.5 and E8.5 with the latter going through a liver monocyte intermediate. The relative potential of these precursors in determining development and functional capacity of M?TR remains unclear. Here, we studied development of alveolar macrophages (AM) after single and competitive transplantation of different precursors from YS, fetal liver, and fetal lung into neonatal Csf2ra?/? mice, which lack endogenous AM. Fetal monocytes, promoted by Myb, outcompeted primitive M? (pM?) in empty AM niches and preferentially developed to mature AM, which is associated with enhanced mitochondrial respiratory and glycolytic capacity and repression of the transcription factors c?Maf and MafB. Interestingly, AM derived from pM? failed to efficiently clear alveolar proteinosis and protect from fatal lung failure following influenza virus infection. Thus, our data demonstrate superior developmental and functional capacity of fetal monocytes over pM? in AM development and underlying mechanisms explaining replacement of pM? in fetal tissues. äFetal monocytes possess increased metabolic capacity and replace primi(epmc).pdf DeepDyve Pubget Overpricing