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10.3389/fimmu.2019.03102 http://scihub22266oqcxt.onion/10.3389/fimmu.2019.03102 C6985362!6985362!32038632     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Immunol 2019 ; 10 (ä): ä Nephropedia Template TP {{tp|p=32038632|t=2019. IL-6 During Influenza-Streptococcus pneumoniae Co-Infected Pneumonia?A Protector |pdf=|usr=}}{{32038632}} gab.com Text IL-6 During Influenza-Streptococcus pneumoniae Co-Infected Pneumonia A Protector JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=32038632 #FOAvip Understanding of pathogenesis and protection mechanisms underlying influenza-Streptococcus pneumoniae co-infection may provide potential strategies for decreasing its high morbidity and mortality. Interleukin-6 (IL-6) is an important cytokine that acts to limit infection-related inflammation; however, its role in co-infected pneumonia remains unclear. Here we show that the clinically relevant co-infected mice displayed dramatically elevated IL-6 levels; which was also observed in patients with co-infected pneumonia. IL-6?/? mice presented with increased bacterial burden, early dissemination of bacteria to extrapulmonary sites accompanied by aggravated pulmonary lesions and high mortality when co-infection. This protective function of IL-6 is associated with cellular death and macrophage function. Importantly, therapeutic administration of recombinant IL-6 protein reduced cells death in BALF, and enhanced macrophage phagocytosis through increased MARCO expression. This protective immune mechanism furthers our understanding of the potential impact of immune components during infection and provides potential therapeutic avenues for influenza-Streptococcus pneumoniae co-infected pneumonia. Twit Text FOAVip IL-6 During Influenza-Streptococcus pneumoniae Co-Infected Pneumonia A Protector ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=32038632 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32038632 #FOAvip English Wikipedia <ref>{{Cite pmid|32038632}}</ref> IL-6 During Influenza-Streptococcus pneumoniae Co-Infected Pneumonia?A Protector #MMPMID32038632 Gou X; Yuan J; Wang H; Wang X; Xiao J; Chen J; Liu S; Yin Y; Zhang X Front Immunol 2019[]; 10 (ä): ä PMID32038632show ga Understanding of pathogenesis and protection mechanisms underlying influenza-Streptococcus pneumoniae co-infection may provide potential strategies for decreasing its high morbidity and mortality. Interleukin-6 (IL-6) is an important cytokine that acts to limit infection-related inflammation; however, its role in co-infected pneumonia remains unclear. Here we show that the clinically relevant co-infected mice displayed dramatically elevated IL-6 levels; which was also observed in patients with co-infected pneumonia. IL-6?/? mice presented with increased bacterial burden, early dissemination of bacteria to extrapulmonary sites accompanied by aggravated pulmonary lesions and high mortality when co-infection. This protective function of IL-6 is associated with cellular death and macrophage function. Importantly, therapeutic administration of recombinant IL-6 protein reduced cells death in BALF, and enhanced macrophage phagocytosis through increased MARCO expression. This protective immune mechanism furthers our understanding of the potential impact of immune components during infection and provides potential therapeutic avenues for influenza-Streptococcus pneumoniae co-infected pneumonia. äIL-6 During Influenza-Streptococcus pneumoniae Co-Infected Pneumonia?A(epmc).pdf DeepDyve Pubget Overpricing