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10.3390/ijms21010323 http://scihub22266oqcxt.onion/10.3390/ijms21010323 C6981685!6981685 !31947724     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=31947724 &cmd=llinks): Failed to open stream: HTTP request failed! 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The Use of Proton Pump Inhibitors May Increase Symptoms of Muscle Function Loss in Patients with Chronic Illnesses |pdf=|usr=}}{{31947724 }} gab.com Text The Use of Proton Pump Inhibitors May Increase Symptoms of Muscle Function Loss in Patients with Chronic Illnesses JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=31947724 #FOAvip Long-term use of proton pump inhibitors (PPIs) is common in patients with muscle wasting-related chronic diseases. We explored the hypothesis that the use of PPIs may contribute to a reduction in muscle mass and function in these patients. Literature indicates that a PPI-induced reduction in acidity of the gastrointestinal tract can decrease the absorption of, amongst others, magnesium. Low levels of magnesium are associated with impaired muscle function. This unwanted side-effect of PPIs on muscle function has been described in different disease backgrounds. Furthermore, magnesium is necessary for activation of vitamin D. Low vitamin D and magnesium levels together can lead to increased inflammation involved in muscle wasting. In addition, PPI use has been described to alter the microbiota's composition in the gut, which might lead to increased inflammation. However, PPIs are often provided together with nonsteroidal anti-inflammatory drugs (NSAIDs), which are anti-inflammatory. In the presence of obesity, additional mechanisms could further contribute to muscle alterations. In conclusion, use of PPIs has been reported to contribute to muscle function loss. Whether this will add to the risk factor for development of muscle function loss in patients with chronic disease needs further investigation. Twit Text FOAVip The Use of Proton Pump Inhibitors May Increase Symptoms of Muscle Function Loss in Patients with Chronic Illnesses ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=31947724 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=31947724 #FOAvip English Wikipedia <ref>{{Cite pmid|31947724 }}</ref> The Use of Proton Pump Inhibitors May Increase Symptoms of Muscle Function Loss in Patients with Chronic Illnesses #MMPMID31947724 Vinke P ; Wesselink E ; van Orten-Luiten W ; van Norren K Int J Mol Sci 2020[Jan]; 21 (1 ): ä PMID31947724 show ga Long-term use of proton pump inhibitors (PPIs) is common in patients with muscle wasting-related chronic diseases. We explored the hypothesis that the use of PPIs may contribute to a reduction in muscle mass and function in these patients. Literature indicates that a PPI-induced reduction in acidity of the gastrointestinal tract can decrease the absorption of, amongst others, magnesium. Low levels of magnesium are associated with impaired muscle function. This unwanted side-effect of PPIs on muscle function has been described in different disease backgrounds. Furthermore, magnesium is necessary for activation of vitamin D. Low vitamin D and magnesium levels together can lead to increased inflammation involved in muscle wasting. In addition, PPI use has been described to alter the microbiota's composition in the gut, which might lead to increased inflammation. However, PPIs are often provided together with nonsteroidal anti-inflammatory drugs (NSAIDs), which are anti-inflammatory. In the presence of obesity, additional mechanisms could further contribute to muscle alterations. In conclusion, use of PPIs has been reported to contribute to muscle function loss. Whether this will add to the risk factor for development of muscle function loss in patients with chronic disease needs further investigation. |Animals [MESH] |Cachexia/*etiology/physiopathology [MESH] |Chronic Disease [MESH] |Gastrointestinal Microbiome/drug effects [MESH] |Humans [MESH] |Magnesium/metabolism [MESH] |Muscles/*drug effects/physiopathology [MESH] |Obesity/complications/physiopathology [MESH] |Proton Pump Inhibitors/*adverse effects [MESH]The Use of Proton Pump Inhibitors May Increase Symptoms of Muscle Func(epmc).pdf DeepDyve Pubget Overpricing