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10.1371/journal.ppat.1008062 http://scihub22266oqcxt.onion/10.1371/journal.ppat.1008062 C6795447!6795447!31585000     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+Pathog 2019 ; 15 (10): ä Nephropedia Template TP {{tp|p=31585000|t=2019. Induction of PGRN by influenza virus inhibits the antiviral immune responses through downregulation of type I interferons signaling |pdf=|usr=}}{{31585000}} gab.com Text Induction of PGRN by influenza virus inhibits the antiviral immune responses through downregulation of type I interferons signaling JO: PLoS Pathog http://www.kidney.de/pget.php?&tw=1&pmid=31585000 #FOAvip Type I interferons (IFNs) play a critical role in host defense against influenza virus infection, and the mechanism of influenza virus to evade type I IFNs responses remains to be fully understood. Here, we found that progranulin (PGRN) was significantly increased both in vitro and in vivo during influenza virus infection. Using a PGRN knockdown assay and PGRN-deficient mice model, we demonstrated that influenza virus-inducing PGRN negatively regulated type I IFNs production by inhibiting the activation of NF-?B and IRF3 signaling. Furthermore, we showed that PGRN directly interacted with NF-?B essential modulator (NEMO) via its Grn CDE domains. We also verified that PGRN recruited A20 to deubiquitinate K63-linked polyubiquitin chains on NEMO at K264. In addition, we found that macrophage played a major source of PGRN during influenza virus infection, and PGRN neutralizing antibodies could protect against influenza virus-induced lethality in mice. Our data identify a PGRN-mediated IFN evasion pathway exploited by influenza virus with implication in antiviral applications. These findings also provide insights into the functions and crosstalk of PGRN in innate immunity. Twit Text FOAVip Induction of PGRN by influenza virus inhibits the antiviral immune responses through downregulation of type I interferons signaling ????PLoS Pathog http://www.kidney.de/pget.php?&tw=1&pmid=31585000 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=31585000 #FOAvip English Wikipedia <ref>{{Cite pmid|31585000}}</ref> Induction of PGRN by influenza virus inhibits the antiviral immune responses through downregulation of type I interferons signaling #MMPMID31585000 Wei F; Jiang Z; Sun H; Pu J; Sun Y; Wang M; Tong Q; Bi Y; Ma X; Gao GF; Liu J PLoS Pathog 2019[Oct]; 15 (10): ä PMID31585000show ga Type I interferons (IFNs) play a critical role in host defense against influenza virus infection, and the mechanism of influenza virus to evade type I IFNs responses remains to be fully understood. Here, we found that progranulin (PGRN) was significantly increased both in vitro and in vivo during influenza virus infection. Using a PGRN knockdown assay and PGRN-deficient mice model, we demonstrated that influenza virus-inducing PGRN negatively regulated type I IFNs production by inhibiting the activation of NF-?B and IRF3 signaling. Furthermore, we showed that PGRN directly interacted with NF-?B essential modulator (NEMO) via its Grn CDE domains. We also verified that PGRN recruited A20 to deubiquitinate K63-linked polyubiquitin chains on NEMO at K264. In addition, we found that macrophage played a major source of PGRN during influenza virus infection, and PGRN neutralizing antibodies could protect against influenza virus-induced lethality in mice. Our data identify a PGRN-mediated IFN evasion pathway exploited by influenza virus with implication in antiviral applications. These findings also provide insights into the functions and crosstalk of PGRN in innate immunity. äInduction of PGRN by influenza virus inhibits the antiviral immune res(epmc).pdf DeepDyve Pubget Overpricing