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10.1002/advs.201901166 http://scihub22266oqcxt.onion/10.1002/advs.201901166 C6755513!6755513!31559137     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Adv+Sci+(Weinh) 2019 ; 6 (18): ä Nephropedia Template TP {{tp|p=31559137|t=2019. Magnesium Regulates Endothelial Barrier Functions through TRPM7, MagT1, and S1P1 |pdf=|usr=}}{{31559137}} gab.com Text Magnesium Regulates Endothelial Barrier Functions through TRPM7, MagT1, and S1P1 JO: Adv Sci (Weinh) http://www.kidney.de/pget.php?&tw=1&pmid=31559137 #FOAvip Mg2+?deficiency is linked to hypertension, Alzheimer's disease, stroke, migraine headaches, cardiovascular diseases, and diabetes, etc., but its exact role in these pathophysiological conditions remains elusive. Mg2+ can regulate vascular functions, yet the mechanistic insight remains ill?defined. Data show that extracellular Mg2+ enters endothelium mainly through the TRPM7 channel and MagT1 transporter. Mg2+ can act as an antagonist to reduce Ca2+ signaling in endothelium. Mg2+ also reduces the intracellular reactive oxygen species (ROS) level and inflammation. In addition, Mg2+?signaling increases endothelial survival and growth, adhesion, and migration. Endothelial barrier integrity is significantly enhanced with Mg2+?treatment through S1P1?Rac1 pathways and barrier?stabilizing mediators including cAMP, FGF1/2, and eNOS. Mg2+ also promotes cytoskeletal reorganization and junction proteins to tighten up the barrier. Moreover, Mg2+?deficiency enhances endothelial barrier permeability in mice, and Mg2+?treatment rescues histamine?induced transient vessel hyper?permeability in vivo. In summary, Mg2+?deficiency can cause deleterious effects in endothelium integrity, and Mg2+?treatment may be effective in the prevention or treatment of vascular dysfunction. Twit Text FOAVip Magnesium Regulates Endothelial Barrier Functions through TRPM7, MagT1, and S1P1 ????Adv Sci (Weinh) http://www.kidney.de/pget.php?&tw=1&pmid=31559137 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=31559137 #FOAvip English Wikipedia <ref>{{Cite pmid|31559137}}</ref> Magnesium Regulates Endothelial Barrier Functions through TRPM7, MagT1, and S1P1 #MMPMID31559137 Zhu D; You J; Zhao N; Xu H Adv Sci (Weinh) 2019[Sep]; 6 (18): ä PMID31559137show ga Mg2+?deficiency is linked to hypertension, Alzheimer's disease, stroke, migraine headaches, cardiovascular diseases, and diabetes, etc., but its exact role in these pathophysiological conditions remains elusive. Mg2+ can regulate vascular functions, yet the mechanistic insight remains ill?defined. Data show that extracellular Mg2+ enters endothelium mainly through the TRPM7 channel and MagT1 transporter. Mg2+ can act as an antagonist to reduce Ca2+ signaling in endothelium. Mg2+ also reduces the intracellular reactive oxygen species (ROS) level and inflammation. In addition, Mg2+?signaling increases endothelial survival and growth, adhesion, and migration. Endothelial barrier integrity is significantly enhanced with Mg2+?treatment through S1P1?Rac1 pathways and barrier?stabilizing mediators including cAMP, FGF1/2, and eNOS. Mg2+ also promotes cytoskeletal reorganization and junction proteins to tighten up the barrier. Moreover, Mg2+?deficiency enhances endothelial barrier permeability in mice, and Mg2+?treatment rescues histamine?induced transient vessel hyper?permeability in vivo. In summary, Mg2+?deficiency can cause deleterious effects in endothelium integrity, and Mg2+?treatment may be effective in the prevention or treatment of vascular dysfunction. äMagnesium Regulates Endothelial Barrier Functions through TRPM7, MagT1(epmc).pdf DeepDyve Pubget Overpricing