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10.3390/medicina55070380 http://scihub22266oqcxt.onion/10.3390/medicina55070380 C6681334!6681334!31315301     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Medicina+(Kaunas) 2019 ; 55 (7): ä Nephropedia Template TP {{tp|p=31315301|t=2019. TRP Channels Expression Profile in Human End-Stage Heart Failure |pdf=|usr=}}{{31315301}} gab.com Text TRP Channels Expression Profile in Human End-Stage Heart Failure JO: Medicina (Kaunas) http://www.kidney.de/pget.php?&tw=1&pmid=31315301 #FOAvip Objectives: Many studies indicate the involvement of transient receptor potential (TRP) channels in the development of heart hypertrophy. However, the data is often conflicted and has originated in animal models. Here, we provide systematic analysis of TRP channels expression in human failing myocardium. Methods and results: Left-ventricular tissue samples were isolated from explanted hearts of NYHA III-IV patients undergoing heart transplants (n = 43). Quantitative real-time PCR was performed to assess the mRNA levels of TRPC, TRPM and TRPV channels. Analysis of functional, clinical and biochemical data was used to confirm an end-stage heart failure diagnosis. Compared to myocardium samples from healthy donor hearts (n = 5), we detected a distinct increase in the expression of TRPC1, TRPC5, TRPM4 and TRPM7, and decreased expression of TRPC4 and TRPV2. These changes were not dependent on gender, clinical or biochemical parameters, nor functional parameters of the heart. We detected, however, a significant correlation of TRPC1 and MEF2c expression. Conclusions: The end-stage heart failure displays distinct expressional changes of TRP channels. Our findings provide a systematic description of TRP channel expression in human heart failure. The results highlight the complex interplay between TRP channels and the need for deeper analysis of early stages of hypertrophy and heart failure development. Twit Text FOAVip TRP Channels Expression Profile in Human End-Stage Heart Failure ????Medicina (Kaunas) http://www.kidney.de/pget.php?&tw=1&pmid=31315301 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=31315301 #FOAvip English Wikipedia <ref>{{Cite pmid|31315301}}</ref> TRP Channels Expression Profile in Human End-Stage Heart Failure #MMPMID31315301 Dragún M; Ga?ová A; Kyselovi? J; Hulman M; Má?u? M Medicina (Kaunas) 2019[Jul]; 55 (7): ä PMID31315301show ga Objectives: Many studies indicate the involvement of transient receptor potential (TRP) channels in the development of heart hypertrophy. However, the data is often conflicted and has originated in animal models. Here, we provide systematic analysis of TRP channels expression in human failing myocardium. Methods and results: Left-ventricular tissue samples were isolated from explanted hearts of NYHA III-IV patients undergoing heart transplants (n = 43). Quantitative real-time PCR was performed to assess the mRNA levels of TRPC, TRPM and TRPV channels. Analysis of functional, clinical and biochemical data was used to confirm an end-stage heart failure diagnosis. Compared to myocardium samples from healthy donor hearts (n = 5), we detected a distinct increase in the expression of TRPC1, TRPC5, TRPM4 and TRPM7, and decreased expression of TRPC4 and TRPV2. These changes were not dependent on gender, clinical or biochemical parameters, nor functional parameters of the heart. We detected, however, a significant correlation of TRPC1 and MEF2c expression. Conclusions: The end-stage heart failure displays distinct expressional changes of TRP channels. Our findings provide a systematic description of TRP channel expression in human heart failure. The results highlight the complex interplay between TRP channels and the need for deeper analysis of early stages of hypertrophy and heart failure development. äTRP Channels Expression Profile in Human End-Stage Heart Failure (epmc).pdf DeepDyve Pubget Overpricing