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10.1126/sciadv.aaw7243 http://scihub22266oqcxt.onion/10.1126/sciadv.aaw7243 C6656542!6656542 !31355337     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=31355337 &cmd=llinks): Failed to open stream: HTTP request failed! 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Cell sensing and decision-making in confinement: The role of TRPM7 in a tug of war between hydraulic pressure and cross-sectional area |pdf=|usr=}}{{31355337 }} gab.com Text Cell sensing and decision-making in confinement: The role of TRPM7 in a tug of war between hydraulic pressure and cross-sectional area JO: Sci Adv http://www.kidney.de/pget.php?&tw=1&pmid=31355337 #FOAvip How cells sense hydraulic pressure and make directional choices in confinement remains elusive. Using trifurcating ?-like microchannels of different hydraulic resistances and cross-sectional areas, we discovered that the TRPM7 ion channel is the critical mechanosensor, which directs decision-making of blebbing cells toward channels of lower hydraulic resistance irrespective of their cross-sectional areas. Hydraulic pressure-mediated TRPM7 activation triggers calcium influx and supports a thicker cortical actin meshwork containing an elevated density of myosin-IIA. Cortical actomyosin shields cells against external forces and preferentially directs cell entrance in low resistance channels. Inhibition of TRPM7 function or actomyosin contractility renders cells unable to sense different resistances and alters the decision-making pattern to cross-sectional area-based partition. Cell distribution in microchannels is captured by a mathematical model based on the maximum entropy principle using cortical actin as a key variable. This study demonstrates the unique role of TRPM7 in controlling decision-making and navigating migration in complex microenvironments. Twit Text FOAVip Cell sensing and decision-making in confinement: The role of TRPM7 in a tug of war between hydraulic pressure and cross-sectional area ????Sci Adv http://www.kidney.de/pget.php?&tw=1&pmid=31355337 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=31355337 #FOAvip English Wikipedia <ref>{{Cite pmid|31355337 }}</ref> Cell sensing and decision-making in confinement: The role of TRPM7 in a tug of war between hydraulic pressure and cross-sectional area #MMPMID31355337 Zhao R ; Afthinos A ; Zhu T ; Mistriotis P ; Li Y ; Serra SA ; Zhang Y ; Yankaskas CL ; He S ; Valverde MA ; Sun SX ; Konstantopoulos K Sci Adv 2019[Jul]; 5 (7 ): eaaw7243 PMID31355337 show ga How cells sense hydraulic pressure and make directional choices in confinement remains elusive. Using trifurcating ?-like microchannels of different hydraulic resistances and cross-sectional areas, we discovered that the TRPM7 ion channel is the critical mechanosensor, which directs decision-making of blebbing cells toward channels of lower hydraulic resistance irrespective of their cross-sectional areas. Hydraulic pressure-mediated TRPM7 activation triggers calcium influx and supports a thicker cortical actin meshwork containing an elevated density of myosin-IIA. Cortical actomyosin shields cells against external forces and preferentially directs cell entrance in low resistance channels. Inhibition of TRPM7 function or actomyosin contractility renders cells unable to sense different resistances and alters the decision-making pattern to cross-sectional area-based partition. Cell distribution in microchannels is captured by a mathematical model based on the maximum entropy principle using cortical actin as a key variable. This study demonstrates the unique role of TRPM7 in controlling decision-making and navigating migration in complex microenvironments. |*Hydrostatic Pressure [MESH] |*Mechanotransduction, Cellular [MESH] |Actomyosin/metabolism [MESH] |Calcium/metabolism [MESH] |Cell Line, Tumor [MESH] |Cell Surface Extensions/metabolism [MESH] |Entropy [MESH] |HEK293 Cells [MESH] |Humans [MESH] |Ion Channel Gating [MESH] |Protein Serine-Threonine Kinases/*metabolism [MESH] |TRPM Cation Channels/*metabolism [MESH]Cell sensing and decision-making in confinement: The role of TRPM7 in (epmc).pdf DeepDyve Pubget Overpricing