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2009 ; 23
(1
): 34-9
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Magnesium and calcium in exhaled breath condensate of children with asthma and
gastroesophageal reflux disease
#MMPMID19140217
Dodig S
; Vlasi? Z
; Cepelak I
; Zrinski Topi? R
; Turkalj M
; Nogalo B
J Clin Lab Anal
2009[]; 23
(1
): 34-9
PMID19140217
show ga
BACKGROUND: Magnesium and calcium physiologic functions are closely related.
Magnesium is primarily an intracellular cation, the action of which also involves
maintenance of cellular ionic balance, while influencing calcium homeostasis by
blocking calcium channels. The aim of this study was to compare the
concentrations of magnesium and calcium in exhaled breath condensate (EBC) of
children with asthma and gastroesophageal reflux disease (GERD). SUBJECTS AND
METHODS: EBC was collected from 66 children aged 7-14 years (23 children with
acute asthma, 17 children with GERD, and 26 healthy children). Determination of
magnesium and calcium concentrations was preceded by optimization and validation
for low concentrations. RESULTS: No difference was recorded for either magnesium
or calcium concentration between study groups. However, the magnesium to calcium
ratio was statistically significantly lower in both GERD and asthma children as
compared with control group. CONCLUSION: Study results showed the magnesium to
calcium ratio to be a statistically significantly better indicator of certain
pathologic changes than absolute concentration of either ion.