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10.1016/j.matbio.2018.06.006 http://scihub22266oqcxt.onion/10.1016/j.matbio.2018.06.006 C6548309!6548309 !29933044     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29933044 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Matrix+Biol 2019 ; 80 (ä): 14-28 Nephropedia Template TP {{tp|p=29933044 |t=2019. Defective lung function following influenza virus is due to prolonged, reversible hyaluronan synthesis |pdf=|usr=}}{{29933044 }} gab.com Text Defective lung function following influenza virus is due to prolonged, reversible hyaluronan synthesis JO: Matrix Biol http://www.kidney.de/pget.php?&tw=1&pmid=29933044 #FOAvip Little is known about the impact of viral infections on lung matrix despite its important contribution to mechanical stability and structural support. The composition of matrix also indirectly controls inflammation by influencing cell adhesion, migration, survival, proliferation and differentiation. Hyaluronan is a significant component of the lung extracellular matrix and production and degradation must be carefully balanced. We have discovered an imbalance in hyaluronan production following resolution of a severe lung influenza virus infection, driven by hyaluronan synthase 2 from epithelial cells, endothelial cells and fibroblasts. Furthermore hyaluronan is complexed with inter-?-inhibitor heavy chains due to elevated TNF-stimulated gene 6 expression and sequesters CD44-expressing macrophages. We show that intranasal administration of exogenous hyaluronidase is sufficient to release inter-?-inhibitor heavy chains, reduce lung hyaluronan content and restore lung function. Hyaluronidase is already used to facilitate dispersion of co-injected materials in the clinic. It is therefore feasible that fibrotic changes following severe lung infection and inflammation could be overcome by targeting abnormal matrix production. Twit Text FOAVip Defective lung function following influenza virus is due to prolonged, reversible hyaluronan synthesis ????Matrix Biol http://www.kidney.de/pget.php?&tw=1&pmid=29933044 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29933044 #FOAvip English Wikipedia <ref>{{Cite pmid|29933044 }}</ref> Defective lung function following influenza virus is due to prolonged, reversible hyaluronan synthesis #MMPMID29933044 Bell TJ ; Brand OJ ; Morgan DJ ; Salek-Ardakani S ; Jagger C ; Fujimori T ; Cholewa L ; Tilakaratna V ; Östling J ; Thomas M ; Day AJ ; Snelgrove RJ ; Hussell T Matrix Biol 2019[Jul]; 80 (ä): 14-28 PMID29933044 show ga Little is known about the impact of viral infections on lung matrix despite its important contribution to mechanical stability and structural support. The composition of matrix also indirectly controls inflammation by influencing cell adhesion, migration, survival, proliferation and differentiation. Hyaluronan is a significant component of the lung extracellular matrix and production and degradation must be carefully balanced. We have discovered an imbalance in hyaluronan production following resolution of a severe lung influenza virus infection, driven by hyaluronan synthase 2 from epithelial cells, endothelial cells and fibroblasts. Furthermore hyaluronan is complexed with inter-?-inhibitor heavy chains due to elevated TNF-stimulated gene 6 expression and sequesters CD44-expressing macrophages. We show that intranasal administration of exogenous hyaluronidase is sufficient to release inter-?-inhibitor heavy chains, reduce lung hyaluronan content and restore lung function. Hyaluronidase is already used to facilitate dispersion of co-injected materials in the clinic. It is therefore feasible that fibrotic changes following severe lung infection and inflammation could be overcome by targeting abnormal matrix production. |Alpha-Globulins/metabolism [MESH] |Animals [MESH] |Cell Adhesion Molecules/metabolism [MESH] |Endothelial Cells/metabolism [MESH] |Epithelial Cells/metabolism [MESH] |Female [MESH] |Fibroblasts/metabolism [MESH] |Humans [MESH] |Hyaluronan Receptors/metabolism [MESH] |Hyaluronan Synthases/*metabolism [MESH] |Hyaluronic Acid/*metabolism [MESH] |Influenza A Virus, H1N1 Subtype/*pathogenicity [MESH] |Influenza, Human/metabolism/*physiopathology [MESH] |Macrophages/immunology [MESH] |Mice [MESH] |Pulmonary Disease, Chronic Obstructive/metabolism/physiopathology/*virology [MESH]Defective lung function following influenza virus is due to prolonged,(epmc).pdf DeepDyve Pubget Overpricing