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10.15252/embj.201899475 http://scihub22266oqcxt.onion/10.15252/embj.201899475 C6518015!6518015!30979777     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       EMBO+J 2019 ; 38 (10): ä Nephropedia Template TP {{tp|p=30979777|t=2019. Co?degradation of interferon signaling factor DDX3 by PB1?F2 as a basis for high virulence of 1918 pandemic influenza |pdf=|usr=}}{{30979777}} gab.com Text Co degradation of interferon signaling factor DDX3 by PB1 F2 as a basis for high virulence of 1918 pandemic influenza JO: EMBO J http://www.kidney.de/pget.php?&tw=1&pmid=30979777 #FOAvip The multifunctional influenza virus protein PB1?F2 plays several roles in deregulation of host innate immune responses and is a known immunopathology enhancer of the 1918 influenza pandemic. Here, we show that the 1918 PB1?F2 protein not only interferes with the mitochondria?dependent pathway of type I interferon (IFN) signaling, but also acquired a novel IFN antagonist function by targeting the DEAD?box helicase DDX3, a key downstream mediator in antiviral interferon signaling, toward proteasome?dependent degradation. Interactome analysis revealed that 1918 PB1?F2, but not PR8 PB1?F2, binds to DDX3 and causes its co?degradation. Consistent with intrinsic protein instability as basis for this gain?of?function, internal structural disorder is associated with the unique cytotoxic sequences of the 1918 PB1?F2 protein. Infusing mice with recombinant DDX3 protein completely rescued them from lethal infection with the 1918 PB1?F2?producing virus. Alongside NS1 protein, 1918 PB1?F2 therefore constitutes a potent IFN antagonist causative for the severe pathogenicity of the 1918 influenza strain. Our identification of molecular determinants of pathogenesis should be useful for the future design of new antiviral strategies against influenza pandemics. Twit Text FOAVip Co degradation of interferon signaling factor DDX3 by PB1 F2 as a basis for high virulence of 1918 pandemic influenza ????EMBO J http://www.kidney.de/pget.php?&tw=1&pmid=30979777 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30979777 #FOAvip English Wikipedia <ref>{{Cite pmid|30979777}}</ref> Co?degradation of interferon signaling factor DDX3 by PB1?F2 as a basis for high virulence of 1918 pandemic influenza #MMPMID30979777 Park E; Byun YH; Park S; Jang YH; Han W; Won J; Cho KC; Kim DH; Lee AR; Shin G; Park YK; Kang HS; Sim H; Ha YN; Jae B; Son A; Kim P; Yu J; Lee H; Kwon S; Kim KP; Lee S; Park Y; Seong BL; Kim K EMBO J 2019[May]; 38 (10): ä PMID30979777show ga The multifunctional influenza virus protein PB1?F2 plays several roles in deregulation of host innate immune responses and is a known immunopathology enhancer of the 1918 influenza pandemic. Here, we show that the 1918 PB1?F2 protein not only interferes with the mitochondria?dependent pathway of type I interferon (IFN) signaling, but also acquired a novel IFN antagonist function by targeting the DEAD?box helicase DDX3, a key downstream mediator in antiviral interferon signaling, toward proteasome?dependent degradation. Interactome analysis revealed that 1918 PB1?F2, but not PR8 PB1?F2, binds to DDX3 and causes its co?degradation. Consistent with intrinsic protein instability as basis for this gain?of?function, internal structural disorder is associated with the unique cytotoxic sequences of the 1918 PB1?F2 protein. Infusing mice with recombinant DDX3 protein completely rescued them from lethal infection with the 1918 PB1?F2?producing virus. Alongside NS1 protein, 1918 PB1?F2 therefore constitutes a potent IFN antagonist causative for the severe pathogenicity of the 1918 influenza strain. Our identification of molecular determinants of pathogenesis should be useful for the future design of new antiviral strategies against influenza pandemics. äCo?degradation of interferon signaling factor DDX3 by PB1?F2 as a basi(epmc).pdf DeepDyve Pubget Overpricing