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10.3390/nu11030641 http://scihub22266oqcxt.onion/10.3390/nu11030641 C6471258!6471258 !30884817     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\30884817 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nutrients 2019 ; 11 (3 ): ä Nephropedia Template TP {{tp|p=30884817 |t=2019. Cyanidin Increases the Expression of Mg(2+) Transport Carriers Mediated by the Activation of PPAR? in Colonic Epithelial MCE301 Cells |pdf=|usr=}}{{30884817 }} gab.com Text Cyanidin Increases the Expression of Mg(2+) Transport Carriers Mediated by the Activation of PPAR in Colonic Epithelial MCE301 Cells JO: Nutrients http://www.kidney.de/pget.php?&tw=1&pmid=30884817 #FOAvip Mg(2+) deficiency may be involved in lifestyle-related diseases, including hypertension, cardiovascular diseases, and diabetes mellitus. Dietary Mg(2+) is absorbed in the intestine mediated through transcellular and paracellular pathways. However, there is little research into what factors upregulate Mg(2+) absorption. We searched for food constituents that can increase the expression levels of Mg(2+) transport carriers using mouse colonic epithelial MCE301 cells. Cyanidin, an anthocyanidin found in black beans and berries, increased the mRNA levels of Mg(2+) transport carriers including transient receptor potential melastatin 6 (TRPM6) channel and cyclin M4 (CNNM4). The cyanidin-induced elevation of Mg(2+) transport carriers was blocked by GW6471, a peroxisome proliferator-activated receptor ? (PPAR?) inhibitor, but not by PPAR?, PPAR?, and protein kinase A inhibitors. Cyanidin-3-glucoside showed similar results to cyanidin. Cyanidin increased the protein levels of TRPM6 and CNNM4, which were distributed in the apical and lateral membranes, respectively. The nuclear localization of PPAR? and reporter activities of Mg(2+) transport carriers were increased by cyanidin, which were inhibited by GW6471. The cyanidin-induced elevation of reporter activity was suppressed by a mutation in a PPAR-response element. Fluorescence measurements using KMG-20, an Mg(2+) indicator, showed that Mg(2+) influx and efflux from the cells were enhanced by cyanidin, and which were inhibited by GW6471. Furthermore, cyanidin increased paracellular Mg(2+) flux without affecting transepithelial electrical resistance. We suggest that cyanidin increases intestinal Mg(2+) absorption mediated by the elevation of TRPM6 and CNNM4 expression, and may constitute a phytochemical that can improve Mg(2+) deficiency. Twit Text FOAVip Cyanidin Increases the Expression of Mg(2+) Transport Carriers Mediated by the Activation of PPAR in Colonic Epithelial MCE301 Cells ????Nutrients http://www.kidney.de/pget.php?&tw=1&pmid=30884817 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30884817 #FOAvip English Wikipedia <ref>{{Cite pmid|30884817 }}</ref> Cyanidin Increases the Expression of Mg(2+) Transport Carriers Mediated by the Activation of PPAR? in Colonic Epithelial MCE301 Cells #MMPMID30884817 Takashina Y ; Manabe A ; Tabuchi Y ; Ikari A Nutrients 2019[Mar]; 11 (3 ): ä PMID30884817 show ga Mg(2+) deficiency may be involved in lifestyle-related diseases, including hypertension, cardiovascular diseases, and diabetes mellitus. Dietary Mg(2+) is absorbed in the intestine mediated through transcellular and paracellular pathways. However, there is little research into what factors upregulate Mg(2+) absorption. We searched for food constituents that can increase the expression levels of Mg(2+) transport carriers using mouse colonic epithelial MCE301 cells. Cyanidin, an anthocyanidin found in black beans and berries, increased the mRNA levels of Mg(2+) transport carriers including transient receptor potential melastatin 6 (TRPM6) channel and cyclin M4 (CNNM4). The cyanidin-induced elevation of Mg(2+) transport carriers was blocked by GW6471, a peroxisome proliferator-activated receptor ? (PPAR?) inhibitor, but not by PPAR?, PPAR?, and protein kinase A inhibitors. Cyanidin-3-glucoside showed similar results to cyanidin. Cyanidin increased the protein levels of TRPM6 and CNNM4, which were distributed in the apical and lateral membranes, respectively. The nuclear localization of PPAR? and reporter activities of Mg(2+) transport carriers were increased by cyanidin, which were inhibited by GW6471. The cyanidin-induced elevation of reporter activity was suppressed by a mutation in a PPAR-response element. Fluorescence measurements using KMG-20, an Mg(2+) indicator, showed that Mg(2+) influx and efflux from the cells were enhanced by cyanidin, and which were inhibited by GW6471. Furthermore, cyanidin increased paracellular Mg(2+) flux without affecting transepithelial electrical resistance. We suggest that cyanidin increases intestinal Mg(2+) absorption mediated by the elevation of TRPM6 and CNNM4 expression, and may constitute a phytochemical that can improve Mg(2+) deficiency. |Animals [MESH] |Anthocyanins/*pharmacology [MESH] |Cation Transport Proteins/*drug effects [MESH] |Cell Line [MESH] |Colon/cytology [MESH] |Epithelial Cells/metabolism [MESH] |Glucosides/pharmacology [MESH] |Intestinal Mucosa/cytology [MESH] |Magnesium Deficiency/metabolism [MESH] |Magnesium/*metabolism [MESH] |Mice [MESH] |Oxazoles/metabolism [MESH] |PPAR alpha/*drug effects [MESH] |Phytochemicals/*pharmacology [MESH] |RNA, Messenger/metabolism [MESH] |TRPM Cation Channels/metabolism [MESH] |Tyrosine/analogs & derivatives/metabolism [MESH]Cyanidin Increases the Expression of Mg(2+) Transport Carriers Mediate(epmc).pdf DeepDyve Pubget Overpricing