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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 NPJ+Prim+Care+Respir+Med
2019 ; 29
(1
): 4
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gab.com Text
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The role of oral magnesium supplements for the management of stable bronchial
asthma: a systematic review and meta-analysis
#MMPMID30778086
Abuabat F
; AlAlwan A
; Masuadi E
; Murad MH
; Jahdali HA
; Ferwana MS
NPJ Prim Care Respir Med
2019[Feb]; 29
(1
): 4
PMID30778086
show ga
Asthma is a chronic lung disease characterized by airway inflammation and
hyper-responsiveness of airway smooth muscles. There is growing evidence that
magnesium may have a role in managing asthma through its dual effect as an
anti-inflammatory and bronchodilating agent. To assess the efficacy of oral
magnesium supplements in chronic asthmatic patients. In addition to searching
through Clinicaltrials.gov/ and references for oral magnesium supplement studies,
we performed a database search in Medline, CINAHL, CENTRAL, and Embase. We
contacted the authors of the included trials to ask for additional information.
We included randomized controlled trials that compared oral magnesium supplements
versus placebo, in addition to standard asthma treatment in mild-moderate
asthmatic adults and children (older than 6 years). Two reviewers independently
performed the study selection, data abstraction, and the assessment of the risk
of bias. Eight trials at moderate risk of bias enrolling a total of 917 patients
were included. Oral magnesium improved FEV1 at week 8 (5.69 (L/min); 95% CI:
1.92, 9.46; I(2): 45%). There was no significant improvement in FEV1 at other
follow up periods. There was no significant change in FVC, Methacholine challenge
test, the frequency of bronchodilator use, or symptoms score. There were no data
on mortality or quality of life. Oral magnesium supplements may lead to
improvement in FEV1 that was only demonstrated at eight weeks; but no effect on
any other outcome. Until future evidence emerges, oral magnesium cannot be
recommended as adjuvants to standard treatment for mild to moderate asthmatic
individuals.
|*Dietary Supplements
[MESH]
|Administration, Oral
[MESH]
|Asthma/*drug therapy
[MESH]
|Bronchodilator Agents/administration & dosage/*therapeutic use
[MESH]