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Magnesium Is a Key Regulator of the Balance between Osteoclast and Osteoblast
Differentiation in the Presence of Vitamin D?
#MMPMID30658432
Mammoli F
; Castiglioni S
; Parenti S
; Cappadone C
; Farruggia G
; Iotti S
; Davalli P
; Maier JAM
; Grande A
; Frassineti C
Int J Mol Sci
2019[Jan]; 20
(2
): ? PMID30658432
show ga
Magnesium (Mg) is crucial for bone health. Low concentrations of Mg inhibit the
activity of osteoblasts while promoting that of osteoclasts, with the final
result of inducing osteopenia. Conversely, little is known about the effects of
high concentrations of extracellular Mg on osteoclasts and osteoblasts. Since the
differentiation and activation of these cells is coordinated by vitamin D? (VD3),
we investigated the effects of high extracellular Mg, as well as its impact on
VD3 activity, in these cells. U937 cells were induced to osteoclastic
differentiation by VD3 in the presence of supra-physiological concentrations (>1
mM) of extracellular Mg. The effect of high Mg concentrations was also studied in
human bone-marrow-derived mesenchymal stem cells (bMSCs) induced to differentiate
into osteoblasts by VD3. We demonstrate that high extra-cellular Mg levels
potentiate VD3-induced osteoclastic differentiation, while decreasing
osteoblastogenesis. We hypothesize that Mg might reprogram VD3 activity on bone
remodeling, causing an unbalanced activation of osteoclasts and osteoblasts.
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