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10.3390/ijms20020385 http://scihub22266oqcxt.onion/10.3390/ijms20020385 C6358963!6358963 !30658432     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=30658432 &cmd=llinks): Failed to open stream: HTTP request failed! 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Magnesium Is a Key Regulator of the Balance between Osteoclast and Osteoblast Differentiation in the Presence of Vitamin D? |pdf=|usr=}}{{30658432 }} gab.com Text Magnesium Is a Key Regulator of the Balance between Osteoclast and Osteoblast Differentiation in the Presence of Vitamin D JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=30658432 #FOAvip Magnesium (Mg) is crucial for bone health. Low concentrations of Mg inhibit the activity of osteoblasts while promoting that of osteoclasts, with the final result of inducing osteopenia. Conversely, little is known about the effects of high concentrations of extracellular Mg on osteoclasts and osteoblasts. Since the differentiation and activation of these cells is coordinated by vitamin D? (VD3), we investigated the effects of high extracellular Mg, as well as its impact on VD3 activity, in these cells. U937 cells were induced to osteoclastic differentiation by VD3 in the presence of supra-physiological concentrations (>1 mM) of extracellular Mg. The effect of high Mg concentrations was also studied in human bone-marrow-derived mesenchymal stem cells (bMSCs) induced to differentiate into osteoblasts by VD3. We demonstrate that high extra-cellular Mg levels potentiate VD3-induced osteoclastic differentiation, while decreasing osteoblastogenesis. We hypothesize that Mg might reprogram VD3 activity on bone remodeling, causing an unbalanced activation of osteoclasts and osteoblasts. Twit Text FOAVip Magnesium Is a Key Regulator of the Balance between Osteoclast and Osteoblast Differentiation in the Presence of Vitamin D ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=30658432 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30658432 #FOAvip English Wikipedia <ref>{{Cite pmid|30658432 }}</ref> Magnesium Is a Key Regulator of the Balance between Osteoclast and Osteoblast Differentiation in the Presence of Vitamin D? #MMPMID30658432 Mammoli F ; Castiglioni S ; Parenti S ; Cappadone C ; Farruggia G ; Iotti S ; Davalli P ; Maier JAM ; Grande A ; Frassineti C Int J Mol Sci 2019[Jan]; 20 (2 ): ä PMID30658432 show ga Magnesium (Mg) is crucial for bone health. Low concentrations of Mg inhibit the activity of osteoblasts while promoting that of osteoclasts, with the final result of inducing osteopenia. Conversely, little is known about the effects of high concentrations of extracellular Mg on osteoclasts and osteoblasts. Since the differentiation and activation of these cells is coordinated by vitamin D? (VD3), we investigated the effects of high extracellular Mg, as well as its impact on VD3 activity, in these cells. U937 cells were induced to osteoclastic differentiation by VD3 in the presence of supra-physiological concentrations (>1 mM) of extracellular Mg. The effect of high Mg concentrations was also studied in human bone-marrow-derived mesenchymal stem cells (bMSCs) induced to differentiate into osteoblasts by VD3. We demonstrate that high extra-cellular Mg levels potentiate VD3-induced osteoclastic differentiation, while decreasing osteoblastogenesis. We hypothesize that Mg might reprogram VD3 activity on bone remodeling, causing an unbalanced activation of osteoclasts and osteoblasts. |*Cell Differentiation [MESH] |Cell Line, Tumor [MESH] |Cell Proliferation/drug effects [MESH] |Cholecalciferol/*metabolism/pharmacology [MESH] |Gene Expression Profiling [MESH] |Humans [MESH] |Macrophages/cytology/drug effects/metabolism [MESH] |Magnesium/*metabolism [MESH] |Mesenchymal Stem Cells/cytology/drug effects/metabolism [MESH] |Monocytes/cytology/drug effects/metabolism [MESH] |Osteoblasts/*cytology/drug effects/*metabolism [MESH] |Osteoclasts/*cytology/drug effects/*metabolism [MESH]Magnesium Is a Key Regulator of the Balance between Osteoclast and Ost(epmc).pdf DeepDyve Pubget Overpricing