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Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Adv+Healthc+Mater 2018 ; 7 (11): e1800132 Nephropedia Template TP
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Micelle-coated, Hierarchically Structured Nanofibers with Dual-release Capability for Accelerated Wound Healing and Infection Control #MMPMID29683273
Albright V; Xu M; Palanisamy A; Cheng J; Stack M; Zhang B; Jayaraman A; Sukhishvili SA; Wang H
Adv Healthc Mater 2018[Jun]; 7 (11): e1800132 PMID29683273show ga
Tailoring nanofibrous matrices ? a material with much promise for wound healing applications ? to simultaneously mitigate bacterial colonization and stimulate wound closure of infected wounds is highly desirable. To that end, a dual-releasing, multiscale system of biodegradable electrospun nanofibers coated with biocompatible micellar nanocarriers is reported. For wound healing, transforming growth factor (TGF)-?1 was incorporated into polycaprolactone/collagen (PCL/Coll) nanofibers via electrospinning and locally stimulated the myofibroblastic differentiation of human dermal fibroblasts. To prevent infection, biocompatible nanocarriers of polypeptide-based block copolymer micelles (BCMs) were deposited onto the surfaces of PCL/Coll nanofibers using tannic acid as a binding partner. Micelle-modified fibrous scaffolds were favorable for wound healing, not only supporting the attachment and spreading of fibroblasts comparable to those on non-coated nanofibers, but also significantly enhancing fibroblast migration. Micellar coatings could be loaded with gentamicin or clindamycin and exhibited antibacterial activity as measured by Petrifilm and zone of inhibition assays as well as time-dependent reduction of cellular counts of Staphylococcus aureus cultures. Moreover, delivery time of antibiotic dosage was tunable through the application of a novel modular approach. Altogether, this system holds great promise as an infection-mitigating, cell-stimulating, biodegradable skin graft for wound management and tissue engineering.