Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1016/j.virol.2018.10.017 http://scihub22266oqcxt.onion/10.1016/j.virol.2018.10.017 C6286381!6286381!30390564     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Virology 2019 ; 526 (ä): 155-64 Nephropedia Template TP {{tp|p=30390564|t=2019. Lack of IFN? signaling attenuates spread of influenza A virus in vivo and leads to reduced pathogenesis |pdf=|usr=}}{{30390564}} gab.com Text Lack of IFN signaling attenuates spread of influenza A virus in vivo and leads to reduced pathogenesis JO: Virology http://www.kidney.de/pget.php?&tw=1&pmid=30390564 #FOAvip IFN? is a key regulator of inflammatory responses but its role in influenza A virus (IAV) pathogenesis is unclear. Our studies show that infection of mice lacking the IFN? receptor (IFN?R-/-) at a dose which caused severe disease in wild type 129?Sv/Ev (WT) mice resulted in milder clinical symptoms and significantly lower lung virus titers by 6 days post-infection (dpi). Viral spread was reduced in IFN?R-/- lungs at 2 and 4 dpi. Levels of inflammatory cytokines and chemokines were lower in IFN?R-/- mice at 2 dpi and there was less infiltration of monocyte/macrophage lineage cells than in WT mice. There was no difference in CD4+ and CD8+ T cells and alveolar macrophages in the bronchoalveolar lavage fluid (BALF) at 2 and 4 dpi but by 4 dpi IFN?R-/- mice had significantly higher percentages of neutrophils. Our data strongly suggest that IAV can use the inflammatory response to promote viral spread. Twit Text FOAVip Lack of IFN signaling attenuates spread of influenza A virus in vivo and leads to reduced pathogenesis ????Virology http://www.kidney.de/pget.php?&tw=1&pmid=30390564 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30390564 #FOAvip English Wikipedia <ref>{{Cite pmid|30390564}}</ref> Lack of IFN? signaling attenuates spread of influenza A virus in vivo and leads to reduced pathogenesis #MMPMID30390564 Nicol MQ; Campbell GM; Shaw DJ; Dransfield I; Ligertwood Y; Beard PM; Nash AA; Dutia BM Virology 2019[Jan]; 526 (ä): 155-64 PMID30390564show ga IFN? is a key regulator of inflammatory responses but its role in influenza A virus (IAV) pathogenesis is unclear. Our studies show that infection of mice lacking the IFN? receptor (IFN?R-/-) at a dose which caused severe disease in wild type 129?Sv/Ev (WT) mice resulted in milder clinical symptoms and significantly lower lung virus titers by 6 days post-infection (dpi). Viral spread was reduced in IFN?R-/- lungs at 2 and 4 dpi. Levels of inflammatory cytokines and chemokines were lower in IFN?R-/- mice at 2 dpi and there was less infiltration of monocyte/macrophage lineage cells than in WT mice. There was no difference in CD4+ and CD8+ T cells and alveolar macrophages in the bronchoalveolar lavage fluid (BALF) at 2 and 4 dpi but by 4 dpi IFN?R-/- mice had significantly higher percentages of neutrophils. Our data strongly suggest that IAV can use the inflammatory response to promote viral spread. äLack of IFN? signaling attenuates spread of influenza A virus in vivo (epmc).pdf DeepDyve Pubget Overpricing