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10.1016/j.virol.2018.10.017 http://scihub22266oqcxt.onion/10.1016/j.virol.2018.10.017 C6286381!6286381 !30390564     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\30390564 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Virology 2019 ; 526 (ä): 155-164 Nephropedia Template TP {{tp|p=30390564 |t=2019. Lack of IFN? signaling attenuates spread of influenza A virus in vivo and leads to reduced pathogenesis |pdf=|usr=}}{{30390564 }} gab.com Text Lack of IFN signaling attenuates spread of influenza A virus in vivo and leads to reduced pathogenesis JO: Virology http://www.kidney.de/pget.php?&tw=1&pmid=30390564 #FOAvip IFN? is a key regulator of inflammatory responses but its role in influenza A virus (IAV) pathogenesis is unclear. Our studies show that infection of mice lacking the IFN? receptor (IFN?R(-/-)) at a dose which caused severe disease in wild type 129?Sv/Ev (WT) mice resulted in milder clinical symptoms and significantly lower lung virus titers by 6 days post-infection (dpi). Viral spread was reduced in IFN?R(-/-) lungs at 2 and 4 dpi. Levels of inflammatory cytokines and chemokines were lower in IFN?R(-/-) mice at 2 dpi and there was less infiltration of monocyte/macrophage lineage cells than in WT mice. There was no difference in CD4(+) and CD8(+) T cells and alveolar macrophages in the bronchoalveolar lavage fluid (BALF) at 2 and 4 dpi but by 4 dpi IFN?R(-/-) mice had significantly higher percentages of neutrophils. Our data strongly suggest that IAV can use the inflammatory response to promote viral spread. Twit Text FOAVip Lack of IFN signaling attenuates spread of influenza A virus in vivo and leads to reduced pathogenesis ????Virology http://www.kidney.de/pget.php?&tw=1&pmid=30390564 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30390564 #FOAvip English Wikipedia <ref>{{Cite pmid|30390564 }}</ref> Lack of IFN? signaling attenuates spread of influenza A virus in vivo and leads to reduced pathogenesis #MMPMID30390564 Nicol MQ ; Campbell GM ; Shaw DJ ; Dransfield I ; Ligertwood Y ; Beard PM ; Nash AA ; Dutia BM Virology 2019[Jan]; 526 (ä): 155-164 PMID30390564 show ga IFN? is a key regulator of inflammatory responses but its role in influenza A virus (IAV) pathogenesis is unclear. Our studies show that infection of mice lacking the IFN? receptor (IFN?R(-/-)) at a dose which caused severe disease in wild type 129?Sv/Ev (WT) mice resulted in milder clinical symptoms and significantly lower lung virus titers by 6 days post-infection (dpi). Viral spread was reduced in IFN?R(-/-) lungs at 2 and 4 dpi. Levels of inflammatory cytokines and chemokines were lower in IFN?R(-/-) mice at 2 dpi and there was less infiltration of monocyte/macrophage lineage cells than in WT mice. There was no difference in CD4(+) and CD8(+) T cells and alveolar macrophages in the bronchoalveolar lavage fluid (BALF) at 2 and 4 dpi but by 4 dpi IFN?R(-/-) mice had significantly higher percentages of neutrophils. Our data strongly suggest that IAV can use the inflammatory response to promote viral spread. |*Signal Transduction/genetics [MESH] |Animals [MESH] |Bronchoalveolar Lavage Fluid/immunology [MESH] |Cytokines/metabolism [MESH] |Influenza A virus/*pathogenicity [MESH] |Interferon gamma Receptor [MESH] |Lung/metabolism/pathology/virology [MESH] |Macrophages/immunology [MESH] |Mice [MESH] |Mice, Transgenic [MESH] |Neutrophils/immunology [MESH] |Orthomyxoviridae Infections/metabolism/*physiopathology/virology [MESH] |Receptors, Interferon/*genetics [MESH]Lack of IFN? signaling attenuates spread of influenza A virus in vivo (epmc).pdf DeepDyve Pubget Overpricing