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10.1186/s12885-018-5050-x http://scihub22266oqcxt.onion/10.1186/s12885-018-5050-x C6258145!6258145 !30477473     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=30477473 &cmd=llinks): Failed to open stream: HTTP request failed! 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TRPM7 overexpression enhances the cancer stem cell-like and metastatic phenotypes of lung cancer through modulation of the Hsp90?/uPA/MMP2 signaling pathway |pdf=|usr=}}{{30477473 }} gab.com Text TRPM7 overexpression enhances the cancer stem cell-like and metastatic phenotypes of lung cancer through modulation of the Hsp90 /uPA/MMP2 signaling pathway JO: BMC Cancer http://www.kidney.de/pget.php?&tw=1&pmid=30477473 #FOAvip BACKGROUND: Waixenicin A, a bioactive extract of soft coral Sarcothelia edmondsoni, has been shown to be anti-neoplastic. However, its mechanisms of action remain unclear. Cancer stem cells (CSCs) and associated stemness factors are implicated in lung cancer. Here, we investigated the role of Waixenicin A on CSCs-like and metastatic lung cancer cells. METHODS: We demonstrated and compared TRPM7 expression in the non-tumor lung tissues or bronchial epithelial 16-HBE cell line. TRPM7 was aberrantly expressed in the cancer tissues and SPCA-1, NCI-H520, SK-MES-1, A549 and 95D cell lines. RESULTS: Increased TRPM7 expression was associated with enhanced SOX2, KLF4, and CD133, Hsp90?, uPA, and MMP2 expression in lung cancer cells. TRPM7-silencing inhibited epithelial-to-mesenchymal transition (EMT), suppressed stemness markers and phenotypes, concomitantly suppressed Hsp90?/uPA/MMP2 axis. Coincidently, Waixenicin A treatment downregulated TRPM7 and oncogenic markers; Waixenicin A also attenuated the ability of lung cancer cells to form tumorspheres, in vitro. In validation, our clinicopathological analyses showed that a higher TRPM7 expression was positively correlated with the larger tumor size (p?=?0.007), positive lymph node metastasis (p?=?0.005) and disease grade (p?=?0.003). CONCLUSIONS: Through its ability to inhibit Hsp90?/uPA/MMP2 signaling and suppress TRPM7 expression, we showed that Waixenicin A is a potential anticancer therapeutic agent for treating malignant lung cancer. Twit Text FOAVip TRPM7 overexpression enhances the cancer stem cell-like and metastatic phenotypes of lung cancer through modulation of the Hsp90 /uPA/MMP2 signaling pathway ????BMC Cancer http://www.kidney.de/pget.php?&tw=1&pmid=30477473 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30477473 #FOAvip English Wikipedia <ref>{{Cite pmid|30477473 }}</ref> TRPM7 overexpression enhances the cancer stem cell-like and metastatic phenotypes of lung cancer through modulation of the Hsp90?/uPA/MMP2 signaling pathway #MMPMID30477473 Liu K ; Xu SH ; Chen Z ; Zeng QX ; Li ZJ ; Chen ZM BMC Cancer 2018[Nov]; 18 (1 ): 1167 PMID30477473 show ga BACKGROUND: Waixenicin A, a bioactive extract of soft coral Sarcothelia edmondsoni, has been shown to be anti-neoplastic. However, its mechanisms of action remain unclear. Cancer stem cells (CSCs) and associated stemness factors are implicated in lung cancer. Here, we investigated the role of Waixenicin A on CSCs-like and metastatic lung cancer cells. METHODS: We demonstrated and compared TRPM7 expression in the non-tumor lung tissues or bronchial epithelial 16-HBE cell line. TRPM7 was aberrantly expressed in the cancer tissues and SPCA-1, NCI-H520, SK-MES-1, A549 and 95D cell lines. RESULTS: Increased TRPM7 expression was associated with enhanced SOX2, KLF4, and CD133, Hsp90?, uPA, and MMP2 expression in lung cancer cells. TRPM7-silencing inhibited epithelial-to-mesenchymal transition (EMT), suppressed stemness markers and phenotypes, concomitantly suppressed Hsp90?/uPA/MMP2 axis. Coincidently, Waixenicin A treatment downregulated TRPM7 and oncogenic markers; Waixenicin A also attenuated the ability of lung cancer cells to form tumorspheres, in vitro. In validation, our clinicopathological analyses showed that a higher TRPM7 expression was positively correlated with the larger tumor size (p?=?0.007), positive lymph node metastasis (p?=?0.005) and disease grade (p?=?0.003). CONCLUSIONS: Through its ability to inhibit Hsp90?/uPA/MMP2 signaling and suppress TRPM7 expression, we showed that Waixenicin A is a potential anticancer therapeutic agent for treating malignant lung cancer. |*Signal Transduction [MESH] |Cell Line, Tumor [MESH] |Gene Expression Regulation, Neoplastic [MESH] |HSP90 Heat-Shock Proteins/*metabolism [MESH] |Humans [MESH] |Immunohistochemistry [MESH] |Kruppel-Like Factor 4 [MESH] |Lung Neoplasms/*genetics/*metabolism/mortality/pathology [MESH] |Matrix Metalloproteinase 2/*metabolism [MESH] |Neoplasm Metastasis [MESH] |Neoplasm Staging [MESH] |Neoplastic Stem Cells/*metabolism [MESH] |Phenotype [MESH] |Prognosis [MESH] |Protein Kinase Inhibitors/pharmacology [MESH] |Protein Serine-Threonine Kinases/antagonists & inhibitors/*genetics [MESH]TRPM7 overexpression enhances the cancer stem cell-like and metastatic(epmc).pdf DeepDyve Pubget Overpricing