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10.1016/j.actbio.2015.11.007

http://scihub22266oqcxt.onion/10.1016/j.actbio.2015.11.007
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C6067679!6067679!26555377
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suck abstract from ncbi


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pmid26555377      Acta+Biomater 2016 ; 30 (ä): 1-12
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  • Engineering growth factors for regenerative medicine applications #MMPMID26555377
  • Mitchell AC; Briquez PS; Hubbell JA; Cochran JR
  • Acta Biomater 2016[Jan]; 30 (ä): 1-12 PMID26555377show ga
  • Growth factors are important morphogenetic proteins that instruct cell behavior and guide tissue repair and renewal. Although their therapeutic potential holds great promise in regenerative medicine applications, translation of growth factors into clinical treatments has been hindered by limitations including poor protein stability, low recombinant expression yield, and suboptimal efficacy. This review highlights current tools, technologies, and approaches to design integrated and effective growth factor-based therapies for regenerative medicine applications. The first section describes rational and combinatorial protein engineering approaches that have been utilized to improve growth factor stability, expression yield, biodistribution, and serum half-life, or alter their cell trafficking behavior or receptor binding affinity. The second section highlights elegant biomaterial-based systems, inspired by the natural extracellular matrix milieu, that have been developed for effective spatial and temporal delivery of growth factors to cell surface receptors. Although appearing distinct, these two approaches are highly complementary and involve principles of molecular design and engineering to be considered in parallel when developing optimal materials for clinical applications.
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