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10.1016/j.it.2007.09.006

http://scihub22266oqcxt.onion/10.1016/j.it.2007.09.006
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C6066088!6066088!18042431
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suck abstract from ncbi


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pmid18042431      Trends+Immunol 2008 ; 29 (1): 4-11
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  • How does HTLV-I persist despite a strong cell-mediated immune response? #MMPMID18042431
  • Asquith B; Bangham CR
  • Trends Immunol 2008[Jan]; 29 (1): 4-11 PMID18042431show ga
  • Human T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that infects human CD4+ T lymphocytes. Despite its presence in T cells, HTLV-1 causes little overt immunosuppression. This host-virus relationship has therefore been exploited as an excellent model system for studying the dynamic interaction between a persistent retrovirus and the normal human immune system. We use a combination of mathematical and experimental techniques to identify key factors on both sides of the in vivo host-virus interaction that significantly determine HTLV-I proviral load and disease risk. We develop a model to describe how these factors interact to enable viral persistence.
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