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10.3892/ijo.2018.4479 http://scihub22266oqcxt.onion/10.3892/ijo.2018.4479 C6065401!6065401 !30015877     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=30015877 &cmd=llinks): Failed to open stream: HTTP request failed! 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Rhaponticin decreases the metastatic and angiogenic abilities of cancer cells via suppression of the HIF?1? pathway |pdf=|usr=}}{{30015877 }} gab.com Text Rhaponticin decreases the metastatic and angiogenic abilities of cancer cells via suppression of the HIF 1 pathway JO: Int J Oncol http://www.kidney.de/pget.php?&tw=1&pmid=30015877 #FOAvip Rhaponticin (RA; 3'5-dihydroxy-4'-methoxystilbene 3-O-?-D?glucopyranoside) is a component isolated from various medicinal herbs including Rheum undulatum L. RA has been reported to be an effective treatment for allergy, diabetes, thrombosis, liver steatosis, lung fibrosis and colitis. In addition, RA effectively inhibits tumor growth and induces apoptosis; however, the effects of RA, at non-cytotoxic doses, on the metastasis and angiogenesis of malignant cancer cells have, to be the best of our knowledge, not been identified. In the present study, it was identified that RA suppressed the metastatic potential of MDA?MB231 breast cancer cells, including colony formation, migration and invasion. Human umbilical vein endothelial cells (HUVECs) treated with RA exhibited a decreased ability to form tube-like networks and to migrate across a Transwell membrane, when compared with RA?untreated HUVECs. Using the chick chorioallantoic membrane assay, RA treatment significantly suppressed spontaneous and vascular endothelial growth factor (VEGF)-induced angiogenesis. Furthermore, RA inhibited the production of pro-angiogenic factors, including matrix metalloproteinase (MMP)-9, pentraxin?3, interleukin-8, VEGF and placental growth factor under normoxic and hypoxic conditions, and suppressed the phorbol 12-myristate 13-acetate-induced increase in the gelatinolytic MMP?9 activity and MMP?9 expression in HT1080 cells. RA also significantly inhibited the hypoxia-inducible factor (HIF)-1? pathway, leading to decreased HIF?1? accumulation and HIF?1? nuclear expression under hypoxia. These results indicated that RA exhibits potent anti?metastatic and anti?angiogenic activities with no cytotoxicity via suppression of the HIF?1? signaling pathway. Thus, RA may control malignant cancer cells by inhibiting the spread from primary tumors and expansion to distant organs. Twit Text FOAVip Rhaponticin decreases the metastatic and angiogenic abilities of cancer cells via suppression of the HIF 1 pathway ????Int J Oncol http://www.kidney.de/pget.php?&tw=1&pmid=30015877 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30015877 #FOAvip English Wikipedia <ref>{{Cite pmid|30015877 }}</ref> Rhaponticin decreases the metastatic and angiogenic abilities of cancer cells via suppression of the HIF?1? pathway #MMPMID30015877 Kim A ; Ma JY Int J Oncol 2018[Sep]; 53 (3 ): 1160-1170 PMID30015877 show ga Rhaponticin (RA; 3'5-dihydroxy-4'-methoxystilbene 3-O-?-D?glucopyranoside) is a component isolated from various medicinal herbs including Rheum undulatum L. RA has been reported to be an effective treatment for allergy, diabetes, thrombosis, liver steatosis, lung fibrosis and colitis. In addition, RA effectively inhibits tumor growth and induces apoptosis; however, the effects of RA, at non-cytotoxic doses, on the metastasis and angiogenesis of malignant cancer cells have, to be the best of our knowledge, not been identified. In the present study, it was identified that RA suppressed the metastatic potential of MDA?MB231 breast cancer cells, including colony formation, migration and invasion. Human umbilical vein endothelial cells (HUVECs) treated with RA exhibited a decreased ability to form tube-like networks and to migrate across a Transwell membrane, when compared with RA?untreated HUVECs. Using the chick chorioallantoic membrane assay, RA treatment significantly suppressed spontaneous and vascular endothelial growth factor (VEGF)-induced angiogenesis. Furthermore, RA inhibited the production of pro-angiogenic factors, including matrix metalloproteinase (MMP)-9, pentraxin?3, interleukin-8, VEGF and placental growth factor under normoxic and hypoxic conditions, and suppressed the phorbol 12-myristate 13-acetate-induced increase in the gelatinolytic MMP?9 activity and MMP?9 expression in HT1080 cells. RA also significantly inhibited the hypoxia-inducible factor (HIF)-1? pathway, leading to decreased HIF?1? accumulation and HIF?1? nuclear expression under hypoxia. These results indicated that RA exhibits potent anti?metastatic and anti?angiogenic activities with no cytotoxicity via suppression of the HIF?1? signaling pathway. Thus, RA may control malignant cancer cells by inhibiting the spread from primary tumors and expansion to distant organs. |Angiogenesis Inhibitors/*pharmacology/therapeutic use [MESH] |Animals [MESH] |Biological Assay [MESH] |Biomarkers, Tumor/metabolism [MESH] |Cell Hypoxia/drug effects [MESH] |Cell Line, Tumor [MESH] |Cell Movement/drug effects [MESH] |Chick Embryo [MESH] |Drug Screening Assays, Antitumor [MESH] |Human Umbilical Vein Endothelial Cells [MESH] |Humans [MESH] |Hypoxia-Inducible Factor 1, alpha Subunit/*metabolism [MESH] |Neoplasms/blood supply/*drug therapy/pathology [MESH] |Neovascularization, Pathologic/*drug therapy/pathology [MESH] |Rheum/chemistry [MESH] |Signal Transduction/*drug effects [MESH] |Stilbenes/*pharmacology/therapeutic use [MESH] |Toxicity Tests [MESH]Rhaponticin decreases the metastatic and angiogenic abilities of cance(epmc).pdf DeepDyve Pubget Overpricing