Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1159/000490338 http://scihub22266oqcxt.onion/10.1159/000490338 C6065105!6065105!29870982     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Kidney+Blood+Press+Res 2018 ; 43 (3): 904-13 Nephropedia Template TP {{tp|p=29870982|t=2018. Tempol Protects Against Acute Renal Injury by Regulating PI3K/Akt/mTOR and GSK3? Signaling Cascades and Afferent Arteriolar Activity |pdf=|usr=}}{{29870982}} gab.com Text Tempol Protects Against Acute Renal Injury by Regulating PI3K/Akt/mTOR and GSK3 Signaling Cascades and Afferent Arteriolar Activity JO: Kidney Blood Press Res http://www.kidney.de/pget.php?&tw=1&pmid=29870982 #FOAvip Background/Aims:: Free radical scavenger tempol is a protective antioxidant against ischemic injury. Tubular epithelial apoptosis is one of the main changes in the renal ischemia/reperfusion (I/R) injury. Meanwhile some proteins related with apoptosis and inflammation are also involved in renal I/R injury. We tested the hypothesis that tempol protects against renal I/R injury by activating protein kinase B/mammalian target of rapamycin (PKB, Akt/mTOR) and glycogen synthase kinase 3? (GSK3?) pathways as well as the coordinating apoptosis and inflammation related proteins. Methods:: The right renal pedicle of C57Bl/6 mouse was clamped for 30 minutes and the left kidney was removed in the study. The renal injury was assessed with serum parameters by an automatic chemistry analyzer. Renal expressions of Akt/mTOR and GSK3? pathways were measured by western blot in I/R mice treated with saline or tempol (50mg/kg) and compared with sham-operated mice. Results:: The levels of blood urea nitrogen (BUN), creatinine and superoxide anion (O2.-) increased, and superoxide dismutase (SOD) and catalase (CAT) decreased significantly after renal I/R injury. However, tempol treatment prevented the changes. Besides, I/R injury reduced renal expression of p-Akt, p-GSK3?, p-mTOR, Bcl2 and increased NF-?B, p-JNK and p53 in kidney, tempol significantly normalized these changes. In addition, renal I/R injury reduced the response of afferent arteriole to Angiotensin II (Ang II), while tempol treatment improved the activity of afferent arteriole. Conclusion:: Tempol attenuates renal I/R injury. The protective mechanisms seem to relate with activation of PI3K/Akt/mTOR and GSK3? pathways, inhibition of cellular damage markers and inflammation factors, as well as improvement of afferent arteriolar activity. Twit Text FOAVip Tempol Protects Against Acute Renal Injury by Regulating PI3K/Akt/mTOR and GSK3 Signaling Cascades and Afferent Arteriolar Activity ????Kidney Blood Press Res http://www.kidney.de/pget.php?&tw=1&pmid=29870982 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29870982 #FOAvip English Wikipedia <ref>{{Cite pmid|29870982}}</ref> Tempol Protects Against Acute Renal Injury by Regulating PI3K/Akt/mTOR and GSK3? Signaling Cascades and Afferent Arteriolar Activity #MMPMID29870982 Zhang G; Wang Q; Wang W; Yu M; Zhang S; Xu N; Zhou S; Cao X; Fu X; Ma Z; Liu R; Mao J; Lai EY Kidney Blood Press Res 2018[]; 43 (3): 904-13 PMID29870982show ga Background/Aims:: Free radical scavenger tempol is a protective antioxidant against ischemic injury. Tubular epithelial apoptosis is one of the main changes in the renal ischemia/reperfusion (I/R) injury. Meanwhile some proteins related with apoptosis and inflammation are also involved in renal I/R injury. We tested the hypothesis that tempol protects against renal I/R injury by activating protein kinase B/mammalian target of rapamycin (PKB, Akt/mTOR) and glycogen synthase kinase 3? (GSK3?) pathways as well as the coordinating apoptosis and inflammation related proteins. Methods:: The right renal pedicle of C57Bl/6 mouse was clamped for 30 minutes and the left kidney was removed in the study. The renal injury was assessed with serum parameters by an automatic chemistry analyzer. Renal expressions of Akt/mTOR and GSK3? pathways were measured by western blot in I/R mice treated with saline or tempol (50mg/kg) and compared with sham-operated mice. Results:: The levels of blood urea nitrogen (BUN), creatinine and superoxide anion (O2.-) increased, and superoxide dismutase (SOD) and catalase (CAT) decreased significantly after renal I/R injury. However, tempol treatment prevented the changes. Besides, I/R injury reduced renal expression of p-Akt, p-GSK3?, p-mTOR, Bcl2 and increased NF-?B, p-JNK and p53 in kidney, tempol significantly normalized these changes. In addition, renal I/R injury reduced the response of afferent arteriole to Angiotensin II (Ang II), while tempol treatment improved the activity of afferent arteriole. Conclusion:: Tempol attenuates renal I/R injury. The protective mechanisms seem to relate with activation of PI3K/Akt/mTOR and GSK3? pathways, inhibition of cellular damage markers and inflammation factors, as well as improvement of afferent arteriolar activity. äTempol Protects Against Acute Renal Injury by Regulating PI3K/Akt/mTOR(epmc).pdf DeepDyve Pubget Overpricing