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10.1073/pnas.1805267115 http://scihub22266oqcxt.onion/10.1073/pnas.1805267115 C6065014!6065014!29987026     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2018 ; 115 (30): E7139-48 Nephropedia Template TP {{tp|p=29987026|t=2018. Superinfection and cure of infected cells as mechanisms for hepatitis C virus adaptation and persistence |pdf=|usr=}}{{29987026}} gab.com Text Superinfection and cure of infected cells as mechanisms for hepatitis C virus adaptation and persistence JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=29987026 #FOAvip Viral populations exhibit an extraordinary ability to survive abrupt changes in host environment by rapidly generating adaptive mutations. However, our understanding of how viral populations respond to selection pressure and the underlying molecular mechanisms supporting viral adaptation in vivo is limited. Here, we report a set of clinical data sampled from subjects chronically infected by hepatitis C virus (HCV). The data show rapid expansion and turnover of drug-resistant viruses following treatment with an HCV protease inhibitor. By fitting mathematical models to the data, we propose that superinfection and cure of infected cells play critical roles in facilitating the rapid expansion and turnover of viral populations. Our results highlight the importance of considering intracellular viral competition in understanding rapid viral adaptation. Twit Text FOAVip Superinfection and cure of infected cells as mechanisms for hepatitis C virus adaptation and persistence ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=29987026 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29987026 #FOAvip English Wikipedia <ref>{{Cite pmid|29987026}}</ref> Superinfection and cure of infected cells as mechanisms for hepatitis C virus adaptation and persistence #MMPMID29987026 Ke R; Li H; Wang S; Ding W; Ribeiro RM; Giorgi EE; Bhattacharya T; Barnard RJO; Hahn BH; Shaw GM; Perelson AS Proc Natl Acad Sci U S A 2018[Jul]; 115 (30): E7139-48 PMID29987026show ga Viral populations exhibit an extraordinary ability to survive abrupt changes in host environment by rapidly generating adaptive mutations. However, our understanding of how viral populations respond to selection pressure and the underlying molecular mechanisms supporting viral adaptation in vivo is limited. Here, we report a set of clinical data sampled from subjects chronically infected by hepatitis C virus (HCV). The data show rapid expansion and turnover of drug-resistant viruses following treatment with an HCV protease inhibitor. By fitting mathematical models to the data, we propose that superinfection and cure of infected cells play critical roles in facilitating the rapid expansion and turnover of viral populations. Our results highlight the importance of considering intracellular viral competition in understanding rapid viral adaptation. äSuperinfection and cure of infected cells as mechanisms for hepatitis (epmc).pdf DeepDyve Pubget Overpricing