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10.1073/pnas.1805267115 http://scihub22266oqcxt.onion/10.1073/pnas.1805267115 C6065014!6065014 !29987026     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29987026 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Proc+Natl+Acad+Sci+U+S+A 2018 ; 115 (30 ): E7139-E7148 Nephropedia Template TP {{tp|p=29987026 |t=2018. Superinfection and cure of infected cells as mechanisms for hepatitis C virus adaptation and persistence |pdf=|usr=}}{{29987026 }} gab.com Text Superinfection and cure of infected cells as mechanisms for hepatitis C virus adaptation and persistence JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=29987026 #FOAvip RNA viruses exist as a genetically diverse quasispecies with extraordinary ability to adapt to abrupt changes in the host environment. However, the molecular mechanisms that contribute to their rapid adaptation and persistence in vivo are not well studied. Here, we probe hepatitis C virus (HCV) persistence by analyzing clinical samples taken from subjects who were treated with a second-generation HCV protease inhibitor. Frequent longitudinal viral load determinations and large-scale single-genome sequence analyses revealed rapid antiviral resistance development, and surprisingly, dynamic turnover of dominant drug-resistant mutant populations long after treatment cessation. We fitted mathematical models to both the viral load and the viral sequencing data, and the results provided strong support for the critical roles that superinfection and cure of infected cells play in facilitating the rapid turnover and persistence of viral populations. More broadly, our results highlight the importance of considering viral dynamics and competition at the intracellular level in understanding rapid viral adaptation. Thus, we propose a theoretical framework integrating viral and molecular mechanisms to explain rapid viral evolution, resistance, and persistence despite antiviral treatment and host immune responses. Twit Text FOAVip Superinfection and cure of infected cells as mechanisms for hepatitis C virus adaptation and persistence ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=29987026 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29987026 #FOAvip English Wikipedia <ref>{{Cite pmid|29987026 }}</ref> Superinfection and cure of infected cells as mechanisms for hepatitis C virus adaptation and persistence #MMPMID29987026 Ke R ; Li H ; Wang S ; Ding W ; Ribeiro RM ; Giorgi EE ; Bhattacharya T ; Barnard RJO ; Hahn BH ; Shaw GM ; Perelson AS Proc Natl Acad Sci U S A 2018[Jul]; 115 (30 ): E7139-E7148 PMID29987026 show ga RNA viruses exist as a genetically diverse quasispecies with extraordinary ability to adapt to abrupt changes in the host environment. However, the molecular mechanisms that contribute to their rapid adaptation and persistence in vivo are not well studied. Here, we probe hepatitis C virus (HCV) persistence by analyzing clinical samples taken from subjects who were treated with a second-generation HCV protease inhibitor. Frequent longitudinal viral load determinations and large-scale single-genome sequence analyses revealed rapid antiviral resistance development, and surprisingly, dynamic turnover of dominant drug-resistant mutant populations long after treatment cessation. We fitted mathematical models to both the viral load and the viral sequencing data, and the results provided strong support for the critical roles that superinfection and cure of infected cells play in facilitating the rapid turnover and persistence of viral populations. More broadly, our results highlight the importance of considering viral dynamics and competition at the intracellular level in understanding rapid viral adaptation. Thus, we propose a theoretical framework integrating viral and molecular mechanisms to explain rapid viral evolution, resistance, and persistence despite antiviral treatment and host immune responses. |*Adaptation, Physiological/drug effects/genetics [MESH] |*Drug Resistance, Viral/drug effects/genetics [MESH] |*Hepacivirus/genetics/metabolism [MESH] |*Hepatitis C/drug therapy/genetics/metabolism [MESH] |*Models, Biological [MESH] |Antiviral Agents/*therapeutic use [MESH]Superinfection and cure of infected cells as mechanisms for hepatitis (epmc).pdf DeepDyve Pubget Overpricing