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Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Proc+Natl+Acad+Sci+U+S+A 2018 ; 115 (30): 7753-8 Nephropedia Template TP
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Anomalous diffusion, spatial coherence, and viscoelasticity from the energy landscape of human chromosomes #MMPMID29987017
Di Pierro M; Potoyan DA; Wolynes PG; Onuchic JN
Proc Natl Acad Sci U S A 2018[Jul]; 115 (30): 7753-8 PMID29987017show ga
Several active processes operate on eukaryotic genomes, dictating their three-dimensional arrangement and dynamical properties. The combination of structural organization and dynamics is essential to the proper functioning of the cell. We show that an effective energy landscape model for chromatin provides a unifying description of both the structural and dynamical aspects of the genome, recapitulating many of its features. Using this quasi-equilibrium energy landscape model, we demonstrate that the physical interactions accounting for genome architecture also lead to the nontrivial dynamical behavior of genomes previously described in multiple experimental observations.