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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Ultrastruct+Pathol
2017 ; 41
(5
): 312-319
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Loss of endothelial planar cell polarity and cellular clearance mechanisms in
age-related macular degeneration
#MMPMID28796562
Campos MM
; Abu-Asab MS
Ultrastruct Pathol
2017[Sep]; 41
(5
): 312-319
PMID28796562
show ga
Apoptosis, autophagosomes, and lysosomes are lacking in the retinal pigment
epithelium (RPE) of age-related macular degeneration (AMD) eyes. Necrosis, not
apoptosis, appeared to be the prominent type of cell death in RPE, which led to
the accumulation of cell debris within and on both sides of Bruch's membrane. The
endothelium of the choriocapillaris had an altered planar cell polarity which
encompassed the disappearance of fenestrations, the thickening of cytoplasm, and
anterior nuclear dislocation. There were no significant differences in RPE and
choroidal aberrations between macular and temporal regions. Loss of endothelial
polarity could be at the crux of AMD initiation and progression.