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10.1097/TP.0b013e31822c6e89 http://scihub22266oqcxt.onion/10.1097/TP.0b013e31822c6e89 C6064209!6064209!21878840     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Transplantation 2011 ; 92 (7): 759-66 Nephropedia Template TP {{tp|p=21878840|t=2011. Ganciclovir Transiently Attenuates Murine Cytomegalovirus-Associated Renal Allograft Inflammation |pdf=|usr=}}{{21878840}} gab.com Text Ganciclovir Transiently Attenuates Murine Cytomegalovirus-Associated Renal Allograft Inflammation JO: Transplantation http://www.kidney.de/pget.php?&tw=1&pmid=21878840 #FOAvip Background.Prophylactic ganciclovir (GCV) is used in high-risk renal transplant patients to prevent acute cytomegalovirus (CMV) disease, but its impact on inflammation within the allograft itself remains undefined. Methods.To study the effect of GCV prophylaxis on allograft inflammation, murine CMV (MCMV)-infected allo-grafts were analyzed in a murine donor positive/recipient negative allogeneic renal transplantation model by flow cytometry and immunofluorescent staining. Results.By flow cytometry, CD45+ leukocyte infiltrates were more abundant in MCMV-infected allografts at 14 days posttransplant compared with uninfected grafts (P<0.01) and decreased in the presence of GCV (P<0.05). CD11c+ dendritic cells, Gr-1+ myeloid cells, CD204+ macrophages, and CD49b+ natural killer cells were reduced in GCV-treated allografts compared with MCMV-infected grafts without GCV treatment (P<0.05). However, GCV failed to reduce these cell types to levels found in MCMV-uninfected allografts. By day 7 after cessation of GCV prophylaxis, dendritic cells, macrophages, and natural killer cells increased in number and became statistically indistinguishable from numbers of cells found in MCMV-infected allografts without GCV. GCV treatment did not affect the numbers of CD4+, CD8+, or CD19+/B220+ lymphocytes infiltrating the allografts. Infiltrates were confirmed histologically by immunofluorescent staining for CD3+ and CD11b+ cells. Conclusions.In this model, MCMV-infected allografts developed significantly greater innate and adaptive leukocytic infiltrates compared with uninfected grafts. GCV attenuated the MCMV-associated innate leukocyte infiltrates in infected allo-grafts but not the lymphocytic infiltrates. The attenuated innate response was limited to the period of GCV prophylaxis. Twit Text FOAVip Ganciclovir Transiently Attenuates Murine Cytomegalovirus-Associated Renal Allograft Inflammation ????Transplantation http://www.kidney.de/pget.php?&tw=1&pmid=21878840 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=21878840 #FOAvip English Wikipedia <ref>{{Cite pmid|21878840}}</ref> Ganciclovir Transiently Attenuates Murine Cytomegalovirus-Associated Renal Allograft Inflammation #MMPMID21878840 Shimamura M; Saunders U; Rha B; Guo L; Cassady KA; George JF; Britt WJ Transplantation 2011[Oct]; 92 (7): 759-66 PMID21878840show ga Background.Prophylactic ganciclovir (GCV) is used in high-risk renal transplant patients to prevent acute cytomegalovirus (CMV) disease, but its impact on inflammation within the allograft itself remains undefined. Methods.To study the effect of GCV prophylaxis on allograft inflammation, murine CMV (MCMV)-infected allo-grafts were analyzed in a murine donor positive/recipient negative allogeneic renal transplantation model by flow cytometry and immunofluorescent staining. Results.By flow cytometry, CD45+ leukocyte infiltrates were more abundant in MCMV-infected allografts at 14 days posttransplant compared with uninfected grafts (P<0.01) and decreased in the presence of GCV (P<0.05). CD11c+ dendritic cells, Gr-1+ myeloid cells, CD204+ macrophages, and CD49b+ natural killer cells were reduced in GCV-treated allografts compared with MCMV-infected grafts without GCV treatment (P<0.05). However, GCV failed to reduce these cell types to levels found in MCMV-uninfected allografts. By day 7 after cessation of GCV prophylaxis, dendritic cells, macrophages, and natural killer cells increased in number and became statistically indistinguishable from numbers of cells found in MCMV-infected allografts without GCV. GCV treatment did not affect the numbers of CD4+, CD8+, or CD19+/B220+ lymphocytes infiltrating the allografts. Infiltrates were confirmed histologically by immunofluorescent staining for CD3+ and CD11b+ cells. Conclusions.In this model, MCMV-infected allografts developed significantly greater innate and adaptive leukocytic infiltrates compared with uninfected grafts. GCV attenuated the MCMV-associated innate leukocyte infiltrates in infected allo-grafts but not the lymphocytic infiltrates. The attenuated innate response was limited to the period of GCV prophylaxis. äGanciclovir Transiently Attenuates Murine Cytomegalovirus-Associated R(epmc).pdf DeepDyve Pubget Overpricing