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Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 BMC+Ophthalmol 2018 ; 18 (ä): ä Nephropedia Template TP
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Factors related to survival outcomes following orbital exenteration: a retrospective, comparative, case series #MMPMID30055580
Aryasit O; Preechawai P; Hirunpat C; Horatanaruang O; Singha P
BMC Ophthalmol 2018[]; 18 (ä): ä PMID30055580show ga
Background: Orbital exenteration is a disfiguring procedure that aims to achieve local control. It is commonly a part of the management of malignant orbital tumor which is a life-threatening condition. It is necessary to determine predictive factors associated with overall survival (OS) following orbital exenteration. Methods: This was a retrospective, comparative, case series of 39 patients with malignant tumors who underwent orbital exenteration. Patient records were reviewed for age, clinical presentation, preoperative visual acuity (VA), tumor size, surgical margin, tumor invasiveness, recurrent disease, and status of distant metastasis. Kaplan-Meier curves were used to assess OS and event-free survival (EFS). The predictive factors related to OS were identified using multivariate analysis. Results: The mean age was 62.9 years (range, 5.5 to 89.7 years), 68.4% presented with VA 20/400. The mean size of all tumors was 32?±?18 mm. Distant metastasis at diagnosis was reported in 11 patients (28.2%). Twenty-two patients died during follow-up. The median OS and EFS were 3.89 years and 3.01 years, respectively. The predictive factors for worse OS on multivariate analysis were preoperative VA 20/400 (adjusted hazard ratio [aHR] 4.67, P?=?0.003), tumor size larger than 20 mm (aHR 3.14, P?=?0.022,) and positive distant metastasis at diagnosis (aHR 15.31, P? 0.001). Conclusions: The prognostic factors for poor survival outcome following orbital exenteration were a preoperative VA 20/400, tumor size >?20 mm, and distant metastasis at diagnosis mostly due to patient negligence.