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10.1038/s41598-018-29434-2 http://scihub22266oqcxt.onion/10.1038/s41598-018-29434-2 C6063949!6063949!30054579     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2018 ; 8 (ä): ä Nephropedia Template TP {{tp|p=30054579|t=2018. Streptozotocin-induced ?-cell damage, high fat diet, and metformin administration regulate Hes3 expression in the adult mouse brain |pdf=|usr=}}{{30054579}} gab.com Text Streptozotocin-induced -cell damage, high fat diet, and metformin administration regulate Hes3 expression in the adult mouse brain JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=30054579 #FOAvip Diabetes mellitus is a group of disorders characterized by prolonged high levels of circulating blood glucose. Type 1 diabetes is caused by decreased insulin production in the pancreas whereas type 2 diabetes may develop due to obesity and lack of exercise; it begins with insulin resistance whereby cells fail to respond properly to insulin and it may also progress to decreased insulin levels. The brain is an important target for insulin, and there is great interest in understanding how diabetes affects the brain. In addition to the direct effects of insulin on the brain, diabetes may also impact the brain through modulation of the inflammatory system. Here we investigate how perturbation of circulating insulin levels affects the expression of Hes3, a transcription factor expressed in neural stem and progenitor cells that is involved in tissue regeneration. Our data show that streptozotocin-induced ?-cell damage, high fat diet, as well as metformin, a common type 2 diabetes medication, regulate Hes3 levels in the brain. This work suggests that Hes3 is a valuable biomarker helping to monitor the state of endogenous neural stem and progenitor cells in the context of diabetes mellitus. Twit Text FOAVip Streptozotocin-induced -cell damage, high fat diet, and metformin administration regulate Hes3 expression in the adult mouse brain ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=30054579 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30054579 #FOAvip English Wikipedia <ref>{{Cite pmid|30054579}}</ref> Streptozotocin-induced ?-cell damage, high fat diet, and metformin administration regulate Hes3 expression in the adult mouse brain #MMPMID30054579 Nikolakopoulou P; Chatzigeorgiou A; Kourtzelis I; Toutouna L; Masjkur J; Arps-Forker C; Poser SW; Rozman J; Rathkolb B; Aguilar-Pimentel JA; Wolf E; Klingenspor M; Ollert M; Schmidt-Weber C; Fuchs H; Gailus-Durner V; Hrabe de Angelis M; Tsata V; Monasor LS; Troullinaki M; Witt A; Anastasiou V; Chrousos G; Yi CX; García-Cáceres C; Tschöp MH; Bornstein SR; Androutsellis-Theotokis A Sci Rep 2018[]; 8 (ä): ä PMID30054579show ga Diabetes mellitus is a group of disorders characterized by prolonged high levels of circulating blood glucose. Type 1 diabetes is caused by decreased insulin production in the pancreas whereas type 2 diabetes may develop due to obesity and lack of exercise; it begins with insulin resistance whereby cells fail to respond properly to insulin and it may also progress to decreased insulin levels. The brain is an important target for insulin, and there is great interest in understanding how diabetes affects the brain. In addition to the direct effects of insulin on the brain, diabetes may also impact the brain through modulation of the inflammatory system. Here we investigate how perturbation of circulating insulin levels affects the expression of Hes3, a transcription factor expressed in neural stem and progenitor cells that is involved in tissue regeneration. Our data show that streptozotocin-induced ?-cell damage, high fat diet, as well as metformin, a common type 2 diabetes medication, regulate Hes3 levels in the brain. This work suggests that Hes3 is a valuable biomarker helping to monitor the state of endogenous neural stem and progenitor cells in the context of diabetes mellitus. äStreptozotocin-induced ?-cell damage, high fat diet, and metformin adm(epmc).pdf DeepDyve Pubget Overpricing