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10.1038/s41467-018-05277-3 http://scihub22266oqcxt.onion/10.1038/s41467-018-05277-3 C6063926!6063926!30054481     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2018 ; 9 (ä): ä Nephropedia Template TP {{tp|p=30054481|t=2018. Lipid droplet and peroxisome biogenesis occur at the same ER subdomains |pdf=|usr=}}{{30054481}} gab.com Text Lipid droplet and peroxisome biogenesis occur at the same ER subdomains JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=30054481 #FOAvip Nascent lipid droplet (LD) formation occurs in the endoplasmic reticulum (ER) membrane but it is not known how sites of biogenesis are determined. We previously identified ER domains in S. cerevisiae containing the reticulon homology domain (RHD) protein Pex30 that are regions where preperoxisomal vesicles (PPVs) form. Here, we show that Pex30 domains are also sites where most nascent LDs form. Mature LDs usually remain associated with Pex30 subdomains, and the same Pex30 subdomain can simultaneously associate with a LD and a PPV or peroxisome. We find that in higher eukaryotes multiple C2 domain containing transmembrane protein (MCTP2) is similar to Pex30: it contains an RHD and resides in ER domains where most nascent LD biogenesis occurs and that often associate with peroxisomes. Together, these findings indicate that most LDs and PPVs form and remain associated with conserved ER subdomains, and suggest a link between LD and peroxisome biogenesis. Twit Text FOAVip Lipid droplet and peroxisome biogenesis occur at the same ER subdomains ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=30054481 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30054481 #FOAvip English Wikipedia <ref>{{Cite pmid|30054481}}</ref> Lipid droplet and peroxisome biogenesis occur at the same ER subdomains #MMPMID30054481 Joshi AS; Nebenfuehr B; Choudhary V; Satpute-Krishnan P; Levine TP; Golden A; Prinz WA Nat Commun 2018[]; 9 (ä): ä PMID30054481show ga Nascent lipid droplet (LD) formation occurs in the endoplasmic reticulum (ER) membrane but it is not known how sites of biogenesis are determined. We previously identified ER domains in S. cerevisiae containing the reticulon homology domain (RHD) protein Pex30 that are regions where preperoxisomal vesicles (PPVs) form. Here, we show that Pex30 domains are also sites where most nascent LDs form. Mature LDs usually remain associated with Pex30 subdomains, and the same Pex30 subdomain can simultaneously associate with a LD and a PPV or peroxisome. We find that in higher eukaryotes multiple C2 domain containing transmembrane protein (MCTP2) is similar to Pex30: it contains an RHD and resides in ER domains where most nascent LD biogenesis occurs and that often associate with peroxisomes. Together, these findings indicate that most LDs and PPVs form and remain associated with conserved ER subdomains, and suggest a link between LD and peroxisome biogenesis. äLipid droplet and peroxisome biogenesis occur at the same ER subdomain(epmc).pdf DeepDyve Pubget Overpricing