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10.1002/btm2.10097 http://scihub22266oqcxt.onion/10.1002/btm2.10097 C6063867!6063867!30065964     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Bioeng+Transl+Med 2018 ; 3 (2): 75-86 Nephropedia Template TP {{tp|p=30065964|t=2018. TGF???responsive CAR?T cells promote anti?tumor immune function |pdf=|usr=}}{{30065964}} gab.com Text TGF responsive CAR T cells promote anti tumor immune function JO: Bioeng Transl Med http://www.kidney.de/pget.php?&tw=1&pmid=30065964 #FOAvip A chimeric antigen receptor (CAR) that responds to transforming growth factor beta (TGF??) enables the engineering of T cells that convert this immunosuppressive cytokine into a potent T?cell stimulant. However, clinical translation of TGF?? CAR?T cells for cancer therapy requires the ability to productively combine TGF?? responsiveness with tumor?targeting specificity. Furthermore, the potential concern that contaminating, TGF???producing regulatory T (Treg) cells may preferentially expand during TGF?? CAR?T cell manufacturing and suppress effector T (Teff) cells demands careful evaluation. Here, we demonstrate that TGF?? CAR?T cells significantly improve the anti?tumor efficacy of neighboring cytotoxic T cells. Furthermore, the introduction of TGF?? CARs into mixed T?cell populations does not result in the preferential expansion of Treg cells, nor do TGF?? CAR?Treg cells cause CAR?mediated suppression of Teff cells. These results support the utility of incorporating TGF?? CARs in the development of adoptive T?cell therapy for cancer. Twit Text FOAVip TGF responsive CAR T cells promote anti tumor immune function ????Bioeng Transl Med http://www.kidney.de/pget.php?&tw=1&pmid=30065964 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30065964 #FOAvip English Wikipedia <ref>{{Cite pmid|30065964}}</ref> TGF???responsive CAR?T cells promote anti?tumor immune function #MMPMID30065964 Hou AJ; Chang ZL; Lorenzini MH; Zah E; Chen YY Bioeng Transl Med 2018[May]; 3 (2): 75-86 PMID30065964show ga A chimeric antigen receptor (CAR) that responds to transforming growth factor beta (TGF??) enables the engineering of T cells that convert this immunosuppressive cytokine into a potent T?cell stimulant. However, clinical translation of TGF?? CAR?T cells for cancer therapy requires the ability to productively combine TGF?? responsiveness with tumor?targeting specificity. Furthermore, the potential concern that contaminating, TGF???producing regulatory T (Treg) cells may preferentially expand during TGF?? CAR?T cell manufacturing and suppress effector T (Teff) cells demands careful evaluation. Here, we demonstrate that TGF?? CAR?T cells significantly improve the anti?tumor efficacy of neighboring cytotoxic T cells. Furthermore, the introduction of TGF?? CARs into mixed T?cell populations does not result in the preferential expansion of Treg cells, nor do TGF?? CAR?Treg cells cause CAR?mediated suppression of Teff cells. These results support the utility of incorporating TGF?? CARs in the development of adoptive T?cell therapy for cancer. äTGF???responsive CAR?T cells promote anti?tumor immune function (epmc).pdf DeepDyve Pubget Overpricing