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10.1038/s41598-018-29341-6 http://scihub22266oqcxt.onion/10.1038/s41598-018-29341-6 C6063850!6063850 !30054495     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\30054495 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2018 ; 8 (1 ): 11344 Nephropedia Template TP {{tp|p=30054495 |t=2018. Blast exposure elicits blood-brain barrier disruption and repair mediated by tight junction integrity and nitric oxide dependent processes |pdf=|usr=}}{{30054495 }} gab.com Text Blast exposure elicits blood-brain barrier disruption and repair mediated by tight junction integrity and nitric oxide dependent processes JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=30054495 #FOAvip Mild blast-induced traumatic brain injury (TBI) is associated with blood-brain barrier (BBB) disruption. However, the mechanisms whereby blast disrupts BBB integrity are not well understood. To address this issue BBB permeability to peripherally injected (14)C-sucrose and (99m)Tc-albumin was quantified in ten brain regions at time points ranging from 0.25 to 72?hours. In mice, repetitive (2X) blast provoked BBB permeability to (14)C-sucrose that persisted in specific brain regions from 0.25 to 72?hours. However, (99m)Tc-albumin revealed biphasic BBB disruption (open-closed-open) over the same interval, which was most pronounced in frontal cortex and hippocampus. This indicates that blast initiates interacting BBB disruption and reparative processes in specific brain regions. Further investigation of delayed (72?hour) BBB disruption revealed that claudin-5 (CLD5) expression was disrupted specifically in the hippocampus, but not in dorsal striatum, a brain region that showed no blast-induced BBB permeability to sucrose or albumin. In addition, we found that delayed BBB permeability and disrupted CLD5 expression were blocked by the nitric oxide synthase inhibitor N(G)-nitro-L-arginine methyl ester (L-NAME). These data argue that latent nitric oxide-dependent signaling pathways initiate processes that result in delayed BBB disruption, which are manifested in a brain-region specific manner. Twit Text FOAVip Blast exposure elicits blood-brain barrier disruption and repair mediated by tight junction integrity and nitric oxide dependent processes ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=30054495 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30054495 #FOAvip English Wikipedia <ref>{{Cite pmid|30054495 }}</ref> Blast exposure elicits blood-brain barrier disruption and repair mediated by tight junction integrity and nitric oxide dependent processes #MMPMID30054495 Logsdon AF ; Meabon JS ; Cline MM ; Bullock KM ; Raskind MA ; Peskind ER ; Banks WA ; Cook DG Sci Rep 2018[Jul]; 8 (1 ): 11344 PMID30054495 show ga Mild blast-induced traumatic brain injury (TBI) is associated with blood-brain barrier (BBB) disruption. However, the mechanisms whereby blast disrupts BBB integrity are not well understood. To address this issue BBB permeability to peripherally injected (14)C-sucrose and (99m)Tc-albumin was quantified in ten brain regions at time points ranging from 0.25 to 72?hours. In mice, repetitive (2X) blast provoked BBB permeability to (14)C-sucrose that persisted in specific brain regions from 0.25 to 72?hours. However, (99m)Tc-albumin revealed biphasic BBB disruption (open-closed-open) over the same interval, which was most pronounced in frontal cortex and hippocampus. This indicates that blast initiates interacting BBB disruption and reparative processes in specific brain regions. Further investigation of delayed (72?hour) BBB disruption revealed that claudin-5 (CLD5) expression was disrupted specifically in the hippocampus, but not in dorsal striatum, a brain region that showed no blast-induced BBB permeability to sucrose or albumin. In addition, we found that delayed BBB permeability and disrupted CLD5 expression were blocked by the nitric oxide synthase inhibitor N(G)-nitro-L-arginine methyl ester (L-NAME). These data argue that latent nitric oxide-dependent signaling pathways initiate processes that result in delayed BBB disruption, which are manifested in a brain-region specific manner. |Albumins/metabolism [MESH] |Animals [MESH] |Blast Injuries/*metabolism/*pathology [MESH] |Blood-Brain Barrier/drug effects/*pathology [MESH] |Brain Injuries, Traumatic/metabolism/pathology [MESH] |Carbon Radioisotopes [MESH] |Claudin-5/metabolism [MESH] |Cyclooxygenase Inhibitors/pharmacology [MESH] |Gliosis/pathology [MESH] |Male [MESH] |Mice, Inbred C57BL [MESH] |NG-Nitroarginine Methyl Ester/pharmacology [MESH] |Nitric Oxide Synthase/antagonists & inhibitors/metabolism [MESH] |Nitric Oxide/*metabolism [MESH] |Organ Specificity [MESH] |Permeability [MESH] |Radiopharmaceuticals/metabolism [MESH] |Sucrose/metabolism [MESH] |Tight Junctions/drug effects/*metabolism [MESH] |Time Factors [MESH]Blast exposure elicits blood-brain barrier disruption and repair media(epmc).pdf DeepDyve Pubget Overpricing