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10.1038/s41598-018-29614-0 http://scihub22266oqcxt.onion/10.1038/s41598-018-29614-0 C6062610!6062610!30050160     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2018 ; 8 (ä): ä Nephropedia Template TP {{tp|p=30050160|t=2018. Quantitative Profiling of the Lymph Node Clearance Capacity |pdf=|usr=}}{{30050160}} gab.com Text Quantitative Profiling of the Lymph Node Clearance Capacity JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=30050160 #FOAvip Transport of tissue-derived lymphatic fluid and clearance by draining lymph nodes are pivotal for maintenance of fluid homeostasis in the body and for immune-surveillance of the self- and non-self-proteomes. Yet a quantitative analysis of nodal filtration of the tissue-derived proteome present in lymphatic fluid has not been reported. Here we quantified the efficiency of nodal clearance of the composite proteomic load using label-free and isotope-labeling proteomic analysis of pre-nodal and post-nodal samples collected by direct cannulation. These results were extended by quantitation of the filtration efficiency of fluorophore-labeled proteins, bacteria, and beads infused at physiological flow rates into pre-nodal lymphatic collectors and collected by post-nodal cannulation. We developed a linear model of nodal filtration efficiency dependent on pre-nodal protein concentrations and molecular weight, and uncovered criteria for disposing the proteome incoming from defined anatomical districts under physiological conditions. These findings are pivotal to understanding the maximal antigenic load sustainable by a draining node, and promote understanding of pathogen spreading and nodal filtration of tumor metastasis, potentially helping to improve design of vaccination protocols, immunization strategies and drug delivery. Twit Text FOAVip Quantitative Profiling of the Lymph Node Clearance Capacity ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=30050160 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30050160 #FOAvip English Wikipedia <ref>{{Cite pmid|30050160}}</ref> Quantitative Profiling of the Lymph Node Clearance Capacity #MMPMID30050160 Clement CC; Wang W; Dzieciatkowska M; Cortese M; Hansen KC; Becerra A; Thangaswamy S; Nizamutdinova I; Moon JY; Stern LJ; Gashev AA; Zawieja D; Santambrogio L Sci Rep 2018[]; 8 (ä): ä PMID30050160show ga Transport of tissue-derived lymphatic fluid and clearance by draining lymph nodes are pivotal for maintenance of fluid homeostasis in the body and for immune-surveillance of the self- and non-self-proteomes. Yet a quantitative analysis of nodal filtration of the tissue-derived proteome present in lymphatic fluid has not been reported. Here we quantified the efficiency of nodal clearance of the composite proteomic load using label-free and isotope-labeling proteomic analysis of pre-nodal and post-nodal samples collected by direct cannulation. These results were extended by quantitation of the filtration efficiency of fluorophore-labeled proteins, bacteria, and beads infused at physiological flow rates into pre-nodal lymphatic collectors and collected by post-nodal cannulation. We developed a linear model of nodal filtration efficiency dependent on pre-nodal protein concentrations and molecular weight, and uncovered criteria for disposing the proteome incoming from defined anatomical districts under physiological conditions. These findings are pivotal to understanding the maximal antigenic load sustainable by a draining node, and promote understanding of pathogen spreading and nodal filtration of tumor metastasis, potentially helping to improve design of vaccination protocols, immunization strategies and drug delivery. äQuantitative Profiling of the Lymph Node Clearance Capacity (epmc).pdf DeepDyve Pubget Overpricing