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Bona fide receptor for hepatitis B and D viral infections: Mechanism, research models and molecular drug targets #MMPMID30050063
Yu Y; Li S; Liang W
Emerg Microbes Infect 2018[]; 7 (ä): ä PMID30050063show ga
Hepatitis B infections have become a serious public health issue globally, and the current first-line antiviral treatment for this disease is not a true cure. Recently, sodium taurocholate cotransporting polypeptide (NTCP), a liver-specific bile acid transporter, was identified as a bona fide receptor for hepatitis B virus (HBV) and its satellite virus, hepatitis delta virus (HDV). Identification of the HBV receptor has led to the development of robust cell cultures and provides a potential target for new treatments. This review summarizes the process by which NTCP was discovered and describes its clinical significance as the receptor for HBV and HDV entry.