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2018 ; 7
(1
): 134
Nephropedia Template TP
gab.com Text
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English Wikipedia
Bona fide receptor for hepatitis B and D viral infections: Mechanism, research
models and molecular drug targets
#MMPMID30050063
Yu Y
; Li S
; Liang W
Emerg Microbes Infect
2018[Jul]; 7
(1
): 134
PMID30050063
show ga
Hepatitis B infections have become a serious public health issue globally, and
the current first-line antiviral treatment for this disease is not a true cure.
Recently, sodium taurocholate cotransporting polypeptide (NTCP), a liver-specific
bile acid transporter, was identified as a bona fide receptor for hepatitis B
virus (HBV) and its satellite virus, hepatitis delta virus (HDV). Identification
of the HBV receptor has led to the development of robust cell cultures and
provides a potential target for new treatments. This review summarizes the
process by which NTCP was discovered and describes its clinical significance as
the receptor for HBV and HDV entry.
|*Molecular Targeted Therapy
[MESH]
|Antiviral Agents/pharmacology/*therapeutic use
[MESH]