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10.1038/s41426-018-0137-7

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C6062556!6062556 !30050063
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suck abstract from ncbi


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pmid30050063
      Emerg+Microbes+Infect 2018 ; 7 (1 ): 134
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  • Bona fide receptor for hepatitis B and D viral infections: Mechanism, research models and molecular drug targets #MMPMID30050063
  • Yu Y ; Li S ; Liang W
  • Emerg Microbes Infect 2018[Jul]; 7 (1 ): 134 PMID30050063 show ga
  • Hepatitis B infections have become a serious public health issue globally, and the current first-line antiviral treatment for this disease is not a true cure. Recently, sodium taurocholate cotransporting polypeptide (NTCP), a liver-specific bile acid transporter, was identified as a bona fide receptor for hepatitis B virus (HBV) and its satellite virus, hepatitis delta virus (HDV). Identification of the HBV receptor has led to the development of robust cell cultures and provides a potential target for new treatments. This review summarizes the process by which NTCP was discovered and describes its clinical significance as the receptor for HBV and HDV entry.
  • |*Molecular Targeted Therapy [MESH]
  • |Antiviral Agents/pharmacology/*therapeutic use [MESH]
  • |Hepatitis B virus/*physiology [MESH]
  • |Hepatitis B/*drug therapy/metabolism [MESH]
  • |Hepatitis D/*drug therapy/metabolism [MESH]
  • |Hepatitis Delta Virus/*physiology [MESH]
  • |Humans [MESH]
  • |Organic Anion Transporters, Sodium-Dependent/metabolism [MESH]
  • |Receptors, Virus/*antagonists & inhibitors/*metabolism [MESH]
  • |Research Design [MESH]
  • |Symporters/metabolism [MESH]
  • |Viral Envelope Proteins/metabolism [MESH]


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