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10.1038/s41388-018-0253-9 http://scihub22266oqcxt.onion/10.1038/s41388-018-0253-9 C6062498!6062498 !29706651     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29706651 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncogene 2018 ; 37 (30 ): 4137-4150 Nephropedia Template TP {{tp|p=29706651 |t=2018. Wild-type p53 upregulates an early onset breast cancer-associated gene GAS7 to suppress metastasis via GAS7-CYFIP1-mediated signaling pathway |pdf=|usr=}}{{29706651 }} gab.com Text Wild-type p53 upregulates an early onset breast cancer-associated gene GAS7 to suppress metastasis via GAS7-CYFIP1-mediated signaling pathway JO: Oncogene http://www.kidney.de/pget.php?&tw=1&pmid=29706651 #FOAvip The early onset breast cancer patients (age???40) often display higher incidence of axillary lymph node metastasis, and poorer five-year survival than the late-onset patients. To identify the genes and molecules associated with poor prognosis of early onset breast cancer, we examined gene expression profiles from paired breast normal/tumor tissues, and coupled with Gene Ontology and public data base analysis. Our data showed that the expression of GAS7b gene was lower in the early onset breast cancer patients as compared to the elder patients. We found that GAS7 was associated with CYFIP1 and WAVE2 complex to suppress breast cancer metastasis via blocking CYFIP1 and Rac1 protein interaction, actin polymerization, and ?1-integrin/FAK/Src signaling. We further demonstrated that p53 directly regulated GAS7 gene expression, which was inversely correlated with p53 mutations in breast cancer specimens. Our study uncover a novel regulatory mechanism of p53 in early onset breast cancer progression through GAS7-CYFIP1-mediated signaling pathways. Twit Text FOAVip Wild-type p53 upregulates an early onset breast cancer-associated gene GAS7 to suppress metastasis via GAS7-CYFIP1-mediated signaling pathway ????Oncogene http://www.kidney.de/pget.php?&tw=1&pmid=29706651 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29706651 #FOAvip English Wikipedia <ref>{{Cite pmid|29706651 }}</ref> Wild-type p53 upregulates an early onset breast cancer-associated gene GAS7 to suppress metastasis via GAS7-CYFIP1-mediated signaling pathway #MMPMID29706651 Chang JW ; Kuo WH ; Lin CM ; Chen WL ; Chan SH ; Chiu MF ; Chang IS ; Jiang SS ; Tsai FY ; Chen CH ; Huang PH ; Chang KJ ; Lin KT ; Lin SC ; Wang MY ; Uen YH ; Tu CW ; Hou MF ; Tsai SF ; Shen CY ; Tung SL ; Wang LH Oncogene 2018[Jul]; 37 (30 ): 4137-4150 PMID29706651 show ga The early onset breast cancer patients (age???40) often display higher incidence of axillary lymph node metastasis, and poorer five-year survival than the late-onset patients. To identify the genes and molecules associated with poor prognosis of early onset breast cancer, we examined gene expression profiles from paired breast normal/tumor tissues, and coupled with Gene Ontology and public data base analysis. Our data showed that the expression of GAS7b gene was lower in the early onset breast cancer patients as compared to the elder patients. We found that GAS7 was associated with CYFIP1 and WAVE2 complex to suppress breast cancer metastasis via blocking CYFIP1 and Rac1 protein interaction, actin polymerization, and ?1-integrin/FAK/Src signaling. We further demonstrated that p53 directly regulated GAS7 gene expression, which was inversely correlated with p53 mutations in breast cancer specimens. Our study uncover a novel regulatory mechanism of p53 in early onset breast cancer progression through GAS7-CYFIP1-mediated signaling pathways. |Adaptor Proteins, Signal Transducing/*genetics [MESH] |Animals [MESH] |Breast Neoplasms/*genetics/pathology [MESH] |Cell Line, Tumor [MESH] |Female [MESH] |Focal Adhesion Kinase 1/genetics [MESH] |Gene Expression Regulation, Neoplastic/genetics [MESH] |Humans [MESH] |Integrin beta1/genetics [MESH] |Lymphatic Metastasis/*genetics/pathology [MESH] |MCF-7 Cells [MESH] |Mice [MESH] |Nerve Tissue Proteins/*genetics [MESH] |Proto-Oncogene Proteins pp60(c-src)/genetics [MESH] |Signal Transduction/*genetics [MESH] |Tumor Suppressor Protein p53/*genetics [MESH] |Up-Regulation/*genetics [MESH]Wild-type p53 upregulates an early onset breast cancer-associated gene(epmc).pdf DeepDyve Pubget Overpricing