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10.1038/s41388-018-0255-7 http://scihub22266oqcxt.onion/10.1038/s41388-018-0255-7 C6062493!6062493 !29706656     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29706656 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncogene 2018 ; 37 (30 ): 4110-4121 Nephropedia Template TP {{tp|p=29706656 |t=2018. The constitutive activity of the virally encoded chemokine receptor US28 accelerates glioblastoma growth |pdf=|usr=}}{{29706656 }} gab.com Text The constitutive activity of the virally encoded chemokine receptor US28 accelerates glioblastoma growth JO: Oncogene http://www.kidney.de/pget.php?&tw=1&pmid=29706656 #FOAvip Glioblastoma (GBM) is the most aggressive and an incurable type of brain cancer. Human cytomegalovirus (HCMV) DNA and encoded proteins, including the chemokine receptor US28, have been detected in GBM tumors. US28 displays constitutive activity and is able to bind several human chemokines, leading to the activation of various proliferative and inflammatory signaling pathways. Here we show that HCMV, through the expression of US28, significantly enhanced the growth of 3D spheroids of U251- and neurospheres of primary glioblastoma cells. Moreover, US28 expression accelerated the growth of glioblastoma cells in an orthotopic intracranial GBM-model in mice. We developed highly potent and selective US28-targeting nanobodies, which bind to the extracellular domain of US28 and detect US28 in GBM tissue. The nanobodies inhibited chemokine binding and reduced the constitutive US28-mediated signaling with nanomolar potencies and significantly impaired HCMV/US28-mediated tumor growth in vitro and in vivo. This study emphasizes the oncomodulatory role of HCMV-encoded US28 and provides a potential therapeutic approach for HCMV-positive tumors using the nanobody technology. Twit Text FOAVip The constitutive activity of the virally encoded chemokine receptor US28 accelerates glioblastoma growth ????Oncogene http://www.kidney.de/pget.php?&tw=1&pmid=29706656 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29706656 #FOAvip English Wikipedia <ref>{{Cite pmid|29706656 }}</ref> The constitutive activity of the virally encoded chemokine receptor US28 accelerates glioblastoma growth #MMPMID29706656 Heukers R ; Fan TS ; de Wit RH ; van Senten JR ; De Groof TWM ; Bebelman MP ; Lagerweij T ; Vieira J ; de Munnik SM ; Smits-de Vries L ; van Offenbeek J ; Rahbar A ; van Hoorick D ; Söderberg-Naucler C ; Würdinger T ; Leurs R ; Siderius M ; Vischer HF ; Smit MJ Oncogene 2018[Jul]; 37 (30 ): 4110-4121 PMID29706656 show ga Glioblastoma (GBM) is the most aggressive and an incurable type of brain cancer. Human cytomegalovirus (HCMV) DNA and encoded proteins, including the chemokine receptor US28, have been detected in GBM tumors. US28 displays constitutive activity and is able to bind several human chemokines, leading to the activation of various proliferative and inflammatory signaling pathways. Here we show that HCMV, through the expression of US28, significantly enhanced the growth of 3D spheroids of U251- and neurospheres of primary glioblastoma cells. Moreover, US28 expression accelerated the growth of glioblastoma cells in an orthotopic intracranial GBM-model in mice. We developed highly potent and selective US28-targeting nanobodies, which bind to the extracellular domain of US28 and detect US28 in GBM tissue. The nanobodies inhibited chemokine binding and reduced the constitutive US28-mediated signaling with nanomolar potencies and significantly impaired HCMV/US28-mediated tumor growth in vitro and in vivo. This study emphasizes the oncomodulatory role of HCMV-encoded US28 and provides a potential therapeutic approach for HCMV-positive tumors using the nanobody technology. |Animals [MESH] |Brain Neoplasms/*genetics/pathology [MESH] |COS Cells [MESH] |Cell Line [MESH] |Cell Proliferation/*genetics [MESH] |Chlorocebus aethiops [MESH] |Cytomegalovirus/*genetics [MESH] |Female [MESH] |Glioblastoma/*genetics/pathology [MESH] |HEK293 Cells [MESH] |Humans [MESH] |Mice [MESH] |Mice, Nude [MESH] |NIH 3T3 Cells [MESH] |Receptors, Chemokine/*genetics [MESH] |Receptors, Virus/genetics [MESH] |Signal Transduction/genetics [MESH]The constitutive activity of the virally encoded chemokine receptor US(epmc).pdf DeepDyve Pubget Overpricing